Korean J Obstet Gynecol.
2004 Aug;47(8):1540-1544.
p53 Codon 72 Polymorphism in Patients with Endometriosis
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
- 2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
- 3Medical Research Center, Department of Pathology, Seoul National University College of Medicine, Korea.
- 4Department of Obstetrics and Gynecology, Eulji University College of Medicine, Korea.
- 5Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Korea.
Abstract
OBJECTIVE
To explore the association of p53 codon 72 polymorphism with endometriosis.
METHODS
Two hundred seventy-one women with surgically or histologically diagnosed edometriosis of stage I-IV, and 219 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Allele frequencies and genotype distribution of p53 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity) in affected women and controls were evaluated.
RESULTS
The genotype distributions of p53 codon 72 polymorphisms did not differ significantly between endometriosis group and control group (p=0.086). However, the genotype distributions of p53 codon 72 polymorphisms differ significantly between stage I-II endometriosis group and control group (p=0.043). Proline homozygotes had higher risk for stage I-II endometriosis compared to arginine homozygotes (odds ratio=2.75, p=0.013).
CONCLUSION
These results suggest that proline homozygote of p53 codon 72 polymorphism is associated with the risk of minimal or mild stage of endometriosis in the Korean population.
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