Korean J Fertil Steril.  2002 Dec;29(4):279-286.

A Study of Estrogen only Therapy and Estrogen Plus Androgen Combination Therapy in Surgical Menopause Patients

• Bai KB

Abstract

OBJECTIVE
To evaluate the difference between estrogen only therapy and estrogen-androgen combination therapy in surgical menopause patients. MATERIALS AND METHOD: Surgical menopause patients received 0.625 mg conjugated equine estrogens or 0.625 mg conjugated equine estrogens plus 1.25 mg methyltestosterone for 2 years. Bone mineral density, menopausal symptoms, lipoprotein profiles were measured.
RESULTS
Both groups showed increased bone mineral density. In the combination group, total cholesterol, high density lipoprotein cholesterol and triglycerides decreased. In the estrogen only group, low density lipoprotein cholesterol decreased but high density lipoprotein cholesterol increased significantly. In both groups, menopausal symptoms were much improved. Side effects were easily tolerated in both groups. CONSLUSIONS: Estrogen-androgen combination therapy had comparable benefits compared with estrogen only therapy.

Keyword

Estrogen-androgen therapy; Surgical menopause

MeSH Terms

Bone Density
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Estrogens*
Estrogens, Conjugated (USP)
Female
Humans
Lipoproteins
Menopause*
Methyltestosterone
Triglycerides
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Estrogens
Estrogens, Conjugated (USP)
Lipoproteins
Methyltestosterone
Triglycerides