J Korean Soc Menopause.  2011 Dec;17(3):136-141. 10.6118/jksm.2011.17.3.136.

Changes of Urinary Tract after Menopause and Effectiveness of Menopausal Hormone Replacement Therapy

Affiliations
  • 1Department of Urology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 2Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. heeobgy@schmc.ac.kr

Abstract

Because sex hormones influence the lower urinary tract, menopause can cause several urinary diseases including overactive bladder, stress urinary incontinence and recurrent urinary tract infection. However, the results of many clinical studies have indicated that menopausal hormone replacement therapy is not effective for the treatment of previous diseases, especially via the oral route. Although estrogen vaginal cream or pessary is an effective treatment for overactive bladders and can prevent recurrent urinary tract infection, its beneficial effects only last for the duration of the treatment. If patients with previous mentioned urologic disease have other local symptoms and conditions, such as atrophic vaginitis and dyspareunia, local estrogen replacement therapy will be helpful in relieving the local symptoms. However, the potential for breast cancer or return of withdrawal of bleeding, patient's age, adverse effect of systemic administration, estrogen-progesterone combination therapy, and effectiveness among other treatment modalities must be considered before a treatment decision can be made. In this article, we will review the current issues on the relationship among urinary tract and sex hormone and menopause, and the effectiveness of menopausal hormone replacement therapy for the treatment of overactive bladders, stress urinary tract incontinence and recurrent urinary tract infection.

Keyword

Hormone replacement therapy; Infection; Menopause; Urinary incontinence; Urinary tract

MeSH Terms

Atrophic Vaginitis
Breast Neoplasms
Dyspareunia
Estrogen Replacement Therapy
Estrogens
Female
Gonadal Steroid Hormones
Hemorrhage
Hormone Replacement Therapy
Humans
Menopause
Pessaries
Urinary Bladder
Urinary Bladder, Overactive
Urinary Incontinence
Urinary Tract
Urinary Tract Infections
Urologic Diseases
Vaginal Creams, Foams, and Jellies
Estrogens
Gonadal Steroid Hormones
Vaginal Creams, Foams, and Jellies

Reference

1. Robinson D, Cardozo L. Estrogens and the lower urinary tract. Neurourol Urodyn. 2011. 30:754–757.
2. Iosif CS, Batra S, Ek A, Astedt B. Estrogen receptors in the human female lower uninary tract. Am J Obstet Gynecol. 1981. 141:817–820.
3. Batra SC, Iosif CS. Progesterone receptors in the female lower urinary tract. J Urol. 1987. 138:1301–1304.
4. Van Geelen JM, Doesburg WH, Thomas CM, Martin CB Jr. Urodynamic studies in the normal menstrual cycle: the relationship between hormonal changes during the menstrual cycle and the urethral pressure profile. Am J Obstet Gynecol. 1981. 141:384–392.
5. Hextall A, Bidmead J, Cardozo L, Hooper R. The impact of the menstrual cycle on urinary symptoms and the results of urodynamic investigation. BJOG. 2001. 108:1193–1196.
6. Rechberger T, Skorupski P. The controversies regarding the role of estrogens in urogynecology. Folia Histochem Cytobiol. 2007. 45:Suppl 1. S17–S21.
7. Samsioe G. Urogenital aging--a hidden problem. Am J Obstet Gynecol. 1998. 178:S245–S249.
8. Hextall A, Cardozo L. The role of estrogen supplementation in lower urinary tract dysfunction. Int Urogynecol J Pelvic Floor Dysfunct. 2001. 12:258–261.
9. Stamey TA, Timothy MM. Studies of introital colonization in women with recurrent urinary infections. I. The role of vaginal pH. J Urol. 1975. 114:261–263.
10. Molander U, Milsom I, Ekelund P, Mellstrom D, Eriksson O. Effect of oral oestriol on vaginal flora and cytology and urogenital symptoms in the post-menopause. Maturitas. 1990. 12:113–120.
11. Milsom I, Arvidsson L, Ekelund P, Molander U, Eriksson O. Factors influencing vaginal cytology, pH and bacterial flora in elderly women. Acta Obstet Gynecol Scand. 1993. 72:286–291.
12. Lee YS, Lee KS, Jung JH, Han DH, Oh SJ, Seo JT, et al. Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study. World J Urol. 2011. 29:185–190.
13. Iosif CS, Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause. Acta Obstet Gynecol Scand. 1984. 63:257–260.
14. Brown JS, Vittinghoff E, Kanaya AM, Agarwal SK, Hulley S, Foxman B. Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factors. Obstet Gynecol. 2001. 98:1045–1052.
15. Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. Urinary tract infection: self-reported incidence and associated costs. Ann Epidemiol. 2000. 10:509–515.
16. Harrington RD, Hooton TM. Urinary tract infection risk factors and gender. J Gend Specif Med. 2000. 3:27–34.
17. Hooton TM, Scholes D, Hughes JP, Winter C, Roberts PL, Stapleton AE, et al. A prospective study of risk factors for symptomatic urinary tract infection in young women. N Engl J Med. 1996. 335:468–474.
18. Falconer C, Ekman G, Malmstrom A, Ulmsten U. Decreased collagen synthesis in stress-incontinent women. Obstet Gynecol. 1994. 84:583–586.
19. Jackson S, Shepherd A, Brookes S, Abrams P. The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial. Br J Obstet Gynaecol. 1999. 106:711–718.
20. Rechberger T, Postawski K, Jakowicki JA, Gunja-Smith Z, Woessner JF Jr. Role of fascial collagen in stress urinary incontinence. Am J Obstet Gynecol. 1998. 179:1511–1514.
21. Jackson S, James M, Abrams P. The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence. BJOG. 2002. 109:339–344.
22. Fleischmann N, Christ G, Sclafani T, Melman A. The effect of ovariectomy and long-term estrogen replacement on bladder structure and function in the rat. J Urol. 2002. 168:1265–1268.
23. Robinson D, Rainer RO, Washburn SA, Clarkson TB. Effects of estrogen and progestin replacement on the urogenital tract of the ovariectomized cynomolgus monkey. Neurourol Urodyn. 1996. 15:215–221.
24. Fantl JA, Cardozo L, McClish DK. Estrogen therapy in the management of urinary incontinence in postmenopausal women: a meta-analysis. First report of the Hormones and Urogenital Therapy Committee. Obstet Gynecol. 1994. 83:12–18.
25. Wilson PD, Faragher B, Butler B, Bu'Lock D, Robinson EL, Brown AD. Treatment with oral piperazine oestrone sulphate for genuine stress incontinence in postmenopausal women. Br J Obstet Gynaecol. 1987. 94:568–574.
26. Moehrer B, Hextall A, Jackson S. Oestrogens for urinary incontinence in women. Cochrane Database Syst Rev. 2003. 2:CD001405.
27. Sultana CJ, Walters MD. Estrogen and urinary incontinence in women. Maturitas. 1994. 20:129–138.
28. Ishiko O, Hirai K, Sumi T, Tatsuta I, Ogita S. Hormone replacement therapy plus pelvic floor muscle exercise for postmenopausal stress incontinence. A randomized, controlled trial. J Reprod Med. 2001. 46:213–220.
29. Cardozo L, Lose G, McClish D, Versi E, de Koning Gans H. A systematic review of estrogens for recurrent urinary tract infections: third report of the hormones and urogenital therapy (HUT) committee. Int Urogynecol J Pelvic Floor Dysfunct. 2001. 12:15–20.
30. Bhatia NN, Bergman A, Karram MM. Effects of estrogen on urethral function in women with urinary incontinence. Am J Obstet Gynecol. 1989. 160:176–181.
31. Simunic V, Banovic I, Ciglar S, Jeren L, Pavicic Baldani D, Sprem M. Local estrogen treatment in patients with urogenital symptoms. Int J Gynaecol Obstet. 2003. 82:187–197.
32. Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical oestrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009. 55:713–719.
33. Ewies AA, Alfhaily F. Topical vaginal estrogen therapy in managing postmenopausal urinary symptoms: a reality or a gimmick? Climacteric. 2010. 13:405–418.
34. Fu X, Rezapour M, Wu X, Li L, Sjogren C, Ulmsten U. Expression of estrogen receptor-alpha and -beta in anterior vaginal walls of genuine stress incontinent women. Int Urogynecol J Pelvic Floor Dysfunct. 2003. 14:276–281.
35. Cody JD, Richardson K, Moehrer B, Hextall A, Glazener CM. Oestrogen therapy for urinary incontinence in post-menopausal women. Cochrane Database Syst Rev. 2009. 4:CD001405.
36. Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993. 329:753–756.
37. Eriksen B. A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women. Am J Obstet Gynecol. 1999. 180:1072–1079.
38. Raz R, Colodner R, Rohana Y, Battino S, Rottensterich E, Wasser I, et al. Effectiveness of estriol-containing vaginal pessaries and nitrofurantoin macrocrystal therapy in the prevention of recurrent urinary tract infection in postmenopausal women. Clin Infect Dis. 2003. 36:1362–1368.
39. Xu R, Wu Y, Hu Y. Prevention and treatment of recurrent urinary system infection with estrogen cream in postmenopausal women. Zhonghua Fu Chan Ke Za Zhi. 2001. 36:531–533.
40. Cardozo L, Benness C, Abbott D. Low dose oestrogen prophylaxis for recurrent urinary tract infections in elderly women. Br J Obstet Gynaecol. 1998. 105:403–407.
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