Korean J Hematol.
2001 Aug;36(3):269-273.
A Case of Natural Killer-Large Granular Lymphocyte (NK-LGL) Leukemia
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Chungnam National University, Taejeon, Korea.
- 2Department of Clinical Pathology, College of Medicine, Chungnam National University, Taejeon, Korea.
Abstract
- Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, is classified into two groups, CD3+ T-LGL leukemia and CD3- NK-LGL leukemia based upon immunophenotype of the cells. We describe a patient with NK-LGL leukemia, who showed a rapidly fatal course. A 56-year-old man was presented with a very high count of white blood cells (154,400/mm3) consisting of mostly LGLs. Immunophenotyping using flow cytometric analysis revealed that majority of the cells were positive for HLA-DR and CD56 but negative for all the myeloid and lymphoid markers. Despite of active supportive care, he died of coagulopathy and multi-organ failure on the sixth hospital day.
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