Korean J Gastroenterol.  1998 Nov;32(5):648-656.

Applications of Individual Value of CA19-9 According to the Clinical Bases in Differentiation of Pancreatico-Biliary Cancer: Analysis Using the Receiver Operating Characteristic (ROC) Curve

• Kim HJ
• Myung SJ
• Yown SY
• Choi WB
• Lee JH
• Park CS
• Youn GH
• Kim SG
• Nam SW
• Yang SH
• Seo DW
• Lee SK
• Kim MH
• Min YI

Abstract

BACKGROUND/AIMS: The aim of our study is to calculate the new individual cut off values of CA19-9 according to the clinical bases, using ROC curve.
METHODS
One hundred and sixty patients with pancreatic diseases, 322 patients with biliary tract diseases and 20,035 asymptomatic controls were enrolled and analyized using ROC curve.
RESULTS
For the patients with pancreatic diseases, CA19-9 was useful to detect the presence of cancer, and its individual cut off value was unchanged according to accompanying disease. For the patients with biliary disease, usefulness of CA19-9 seemed to be significantly better in the group of the patients without cholangitis or cholestasis (sensitivity 77.6%, specificity 83%) than in group of patients with cholangitis or cholestasis (sensitivity 74.4%, specificity 41.5%). For asymptomatic persons, the positive predictive value of CA19-9 was 0.65%.
CONCLUSIONS
For the differentiation of pancreatiocobiliary cancer, CA19-9 should be used individually according to the clinical bases, origin of cancer and accompanying diseases. CA19-9 may not be recommended for screening to detect pancreaticobiliary diseases in persons without any symptoms.

Keyword

CA19-9; Pancreatic cancer; Bile duct cancer

MeSH Terms

Bile Duct Neoplasms
Biliary Tract Diseases
Cholangitis
Cholestasis
Humans
Mass Screening
Pancreatic Diseases
Pancreatic Neoplasms
ROC Curve*
Sensitivity and Specificity