Lack of Association between Individual Symptoms and Gastric Hypersensitivity in Functional Dyspepsia

Kim, Young Ho; Rhee, Poong Lyul; Lee, Hwa Young; Son, Hee Jung; Kim, Jae Jun; Koh, Kwang Cheol; Paik, Seung Woon; Rhee, Jong Chul; Choi, Kyoo Wan; He, Jin Seok; Noh, Jae Hyung

Abstract

BACKGROUND/AIMS: Gastric hypersensitivity is an important factor in the pathophysiology of functionl dyspepsia (FD). However, It is unclear whether the analysis of individual symptoms can predict the presence of gastric hypersensitivity. We evaluated the relation between common symptoms of FD and various parameters measured by gastric barostat in FD patients.
METHODS
Gastric barostat tests were performed in 64 FD patients and 20 healthy control subjects without gastrointestinal symptoms. Individual symptoms such as early satiety, postprandial fullness, delayed emptying sense, nausea, vomiting and epigastric soreness were collected and graded from mild to severe.
RESULTS
Basal tones and gastric compliances were similar in controls and patients. Threshold of abdominal discomfort was lower in FD patients than in controls (8.9+/-3.6 mmHg and 14.5+/-3.7 mmHg, respectively, p<0.05), but there were no significant differences in threshold of abdominal discomfort according to the severity of individual symptoms.
CONCLUSIONS
The simple evaluation of the individual symptoms could not predict the presence of gastric hypersensitivity.