Korean J Dermatol.
1999 Mar;37(3):371-375.
A Case of Generalized Lichen Planus Cured by Griseofulvin
Abstract
- Although a number of remedies like corticosteroids, retinoids, griseofulvin, PUVA, cyclosporine, antibiotics, dapsone, cyclophosphamide, surgery, methotrexate, radiation therapy, antimalarial drugs, psychotharapy and psychiatric medications have been used to treat lichen planus, there were no specific methods until now. We report herein an interesting case of lichen planus in which complete healing was achieved by griseofulvin administration. The patient was a 54-year-old male who for 3 months had variouly sized and shaped, flat-topped, scaly, violaceous papules and plaques on the whole of his body. We confirmed the patients disease as lichen planus by a histopathologic examination of a skin biopsy specimen and gave him 500mg ultramicronized griseofulvin daily in divided dosages. After 12 weeks of the medication nearly all of the skin lesions were regressed, and by 14 weeks all skin lesions had disappeared leaving hyperpigmentation. Up to now, l9 months after discontinuation of the medication, no recurrence of the disease has been noted.
Keyword
MeSH Terms
-
Adrenal Cortex Hormones
Anti-Bacterial Agents
Antimalarials
Biopsy
Cyclophosphamide
Cyclosporine
Dapsone
Griseofulvin*
Humans
Hyperpigmentation
Lichen Planus*
Lichens*
Male
Methotrexate
Middle Aged
Recurrence
Retinoids
Skin
Adrenal Cortex Hormones
Anti-Bacterial Agents
Antimalarials
Cyclophosphamide
Cyclosporine
Dapsone
Griseofulvin
Methotrexate
Retinoids
