Korean J Hematol.  1999 Feb;34(1):153-156.

T-Cell Lymphoma with Rosai-Dorfman Syndrome-Like Feature

Affiliations
  • 1Department of Internal Medicine, Holy Family Hospital, The Catholic University of Korea, College Of Medicine, Puchun, Korea.
  • 2Department of Clinical Pathology, Holy Family Hospital, The Catholic University of Korea, College Of Medicine, Puchun, Korea.

Abstract

T-cell lymphoma is heterogeneous with respect to clinical presentation, course, and morphology, but it is rarely associated with sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Syndrome). We report a case of T-cell lymphoma with Rosai-Dorfman Syndrome like feature in a 31-years-old woman who presented severe non-immune hemolytic anemia and massive retroperitoneal and cervical lymphadenopathy. Her cervical lymph node biopsy revealed histiocytic infiltration showing erythrophagocytosis without marked fibrosis in the capsular and pericapsular areas and distension of sinusoids. After 6 cycles of CHOP (Cyclophosphamide, Adriamycin, Vincristine, and Prednisolone) chemotherapy, cervical and retroperitoneal lymphadenopathy was completely disappeared and according to the resolution of lymphadenopathy hemolytic anemia was also improved.

Keyword

Rosai-Dorfman Syndrome; T-cell lymphoma

MeSH Terms

Anemia, Hemolytic
Biopsy
Doxorubicin
Drug Therapy
Female
Fibrosis
Histiocytosis, Sinus
Humans
Lymph Nodes
Lymphatic Diseases
Lymphoma, T-Cell*
T-Lymphocytes*
Vincristine
Doxorubicin
Vincristine
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