Korean J Hematol.  1999 Nov;34(4):641-645.

A Case with Disseminated Macrophage-related Histiocytic Sarcoma Diagnosed by Positive Histiocytic Markers

• Kim KW
• Park SY
• Kim HJ
• Yoo BH
• Kang SB
• Lee JP
• Lee EH
• Lee KS

Abstract

Malignant histiocytosis (MH) is characterized by an invasive, progressive proliferation of neoplastic histiocytes associated with jaundice, lymphadenopathy, refractory anemia, leukopenia, and often hepatic and splenic enlargement. As lymphoblastic leukemia and lymphoma are regarded as neoplasms of lymphoid cells, MH is thought to represent a malignant transformation of the macrophage and dendritic cells. A classification of malignant histiocytic disorders was oriented by cell lineage in the Histiocyte Society's 1987 version. So dendritic cell-related histiocytic sarcoma (localized or disseminated) and macrophage-related histiocytic sarcoma (localized or disseminated) are the recommended nosology. To establish the correct diagnosis, the major challenge seems to distinguish lymphoid from histiocytic cells. M-CSF receptor, lysozyme, Ki-M8, and S-100 protein, etc are useful markers for histiocytes and T-cell and B-cell lineage markers, such as CD3, CD20, and CD79, etc, for lymphocytes. We have experienced a patient with disseminated histiocytic sarcoma diagnosed by positive istiocytic markers, such as lysozyme, S-100 protein, and CD68.

Keyword

Malignant Histiocytosis; Histiocytic Sarcoma

MeSH Terms

Anemia, Refractory
B-Lymphocytes
Cell Lineage
Classification
Dendritic Cells
Diagnosis
Histiocytes
Histiocytic Disorders, Malignant
Histiocytic Sarcoma*
Humans
Jaundice
Leukopenia
Lymphatic Diseases
Lymphocytes
Lymphoma
Macrophage Colony-Stimulating Factor
Macrophages
Muramidase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
S100 Proteins
T-Lymphocytes
Macrophage Colony-Stimulating Factor
Muramidase
S100 Proteins