Nucl Med Mol Imaging.  2007 Jun;41(3):247-251.

A Significant Discrepancy of Uptake between I-131 MIBG and F-18 FDG in a Patient With Malignant Paraganglioma

• Kim JS
• Kim HK
• Choi KY
• Park HK
• Kim ES
• Kim YK
• Kim S
• Kim YJ
• Lee HJ

Abstract

A 38-year-old man who was diagnosed with malignant paraganglioma underwent computed tomography (CT) and I-131 metaiodobenzylguanidine (MIBG) san. CT showed extensive lymph node enlargement in right iliac area and retroperitoneum with severe hydronephrosis and mass on posterior bladder wall. However, I-131 MIBG scan didn't showed abnormal uptake. He also underwent F-18 fluorodeoxyglucose (FDG) positron emisson tomography/CT for localizing accurate tumor site. F-18 FDG PET/CT showed multiple metastases of left supraclavicular, hilar, mediastinal para-aortic, inguinal, right iliac lymph nodes, lung, vertebrae, and pelvis. There are a few reports showing that the F-18 FDG PET/CT is helpful for staging and localizing tumor site of patients who are diagnosed with negative on the MIBG scans. Thus, we report a case with paraganglioma which showed negative I-131 MIBG scan, but revealed multiple intense hypermetabolic foci in F-18 FDG PET/CT.

Keyword

paraganglioma; F-18 FDG PET/CT; I-131 MIBG scan

MeSH Terms

3-Iodobenzylguanidine*
Adult
Electrons
Humans
Hydronephrosis
Lung
Lymph Nodes
Neoplasm Metastasis
Paraganglioma*
Pelvis
Positron-Emission Tomography and Computed Tomography
Spine
Urinary Bladder
3-Iodobenzylguanidine