Nucl Med Mol Imaging.  2018 Aug;52(4):254-265. 10.1007/s13139-018-0523-z.

Current Consensus on I-131 MIBG Therapy

• Kayano D
• Kinuya S

• KMID: 2418989
• DOI: http://doi.org/10.1007/s13139-018-0523-z

Abstract

Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine and specifically targets neuroendocrine cells including some neuroendocrine tumors. Iodine-131 (I-131)-labeled MIBG (I-131 MIBG) therapy for neuroendocrine tumors has been performed for more than a quarter-century. The indications of I-131 MIBG therapy include treatment-resistant neuroblastoma (NB), unresectable or metastatic pheochromocytoma (PC) and paraganglioma (PG), unresectable or metastatic carcinoid tumors, and unresectable or metastatic medullary thyroid cancer (MTC). I-131 MIBG therapy is one of the considerable effective treatments in patients with advanced NB, PC, and PG. On the other hand, I-131 MIBG therapy is an alternative method after more effective novel therapies are used such as radiolabeled somatostatin analogs and tyrosine kinase inhibitors in patients with advanced carcinoid tumors and MTC. No-carrier-aided (NCA) I-131 MIBG has more favorable potential compared to the conventional I-131 MIBG. Astatine-211-labeled meta-astatobenzylguanidine (At-211 MABG) has massive potential in patients with neuroendocrine tumors. Further studies about the therapeutic protocols of I-131 MIBG including NCA I-131 MIBG in the clinical setting and At-211 MABG in both the preclinical and clinical settings are needed.

Keyword

Iodine-131 metaiodobenzylguanidine; Neuroblastoma; Pheochromocytoma; Paraganglioma; Carcinoid tumors; Medullary thyroid cancer

MeSH Terms

3-Iodobenzylguanidine*
Carcinoid Tumor
Consensus*
Hand
Humans
Methods
Neuroblastoma
Neuroendocrine Cells
Neuroendocrine Tumors
Neurotransmitter Agents
Norepinephrine
Paraganglioma
Pheochromocytoma
Protein-Tyrosine Kinases
Somatostatin
Thyroid Neoplasms
3-Iodobenzylguanidine
Neurotransmitter Agents
Norepinephrine
Protein-Tyrosine Kinases
Somatostatin