Korean J Biol Psychiatry.  2006 Aug;13(3):170-177.

Association between Social Phobia and Serotonin Transporter Gene Polymorphism: Preliminary Study

• Lee JH
• Lim SW
• Oh KS
• Lee MS

Abstract

ele frequency analysis, a significant association was also observed between the short allele and social phobia(p=.030). A significant associations between S genotype and each subgroup were observed(GEN p=.045 ; NGEN p=.033), but there were no differences in allele frequency. And, no differences in genotype and allele distribution between two subgroups were found.
CONCLUSION
The results in our Korean sample suggest that S genotype of 5-HTTLPR may be associated with social phobia and s allele may be an important genetic factor that activates social phobic symptoms. But, further studies including large number of samples are necessary to elucidate these present findings.

Keyword

Social phobia; Serotonin trasporter(5-HTT); Polymorphism

MeSH Terms

Alleles
Gene Frequency
Genotype
Phobic Disorders*
Serotonin Plasma Membrane Transport Proteins*
Serotonin*
Serotonin
Serotonin Plasma Membrane Transport Proteins