Korean J Biol Psychiatry.  2011 Feb;18(1):15-24.

Understanding of Neural Mechanism of Mood Disorders: Focused on Neuroimaging Findings

Affiliations
  • 1Department of Psychiatry, The Catholic University of Korea College of Medicine, Uijeongbu, Korea. mindcure@catholic.ac.kr

Abstract

Mood disorder is unlikely to be a disease of a single brain region or a neurotransmitter system. Rather, it is now generally viewed as a multidimensional disorder that affects many neural pathways. Growing neuroimaging evidence suggests the anterior cingulate-pallidostriatal-thalamic-amygdala circuit as a putative cortico-limbic mood regulating circuit that may be dysfunctional in mood disorders. Brain-imaging techniques have shown increased activation of mood-generating limbic areas and decreased activation of cortical areas in major depressive disorder(MDD). Furthermore, the combination of functional abnormalities in limbic subcortical neural regions implicated in emotion processing together with functional abnormalities of prefrontal cortical neural regions probably result in the emotional lability and impaired ability to regulate emotion in bipolar disorder. Here we review the biological correlates of MDD and bipolar disorder as evidenced by neuroimaging paradigms, and interpret these data from the perspective of endophenotype. Despite possible limitations, we believe that the integration of neuroimaging research findings will significantly advance our understanding of affective neuroscience and provide novel insights into mood disorders.

Keyword

Mood disorders; Depression; Bipolar disorder; Neuroimaging

MeSH Terms

Bipolar Disorder
Brain
Depression
Endophenotypes
Mood Disorders
Neural Pathways
Neuroimaging
Neurosciences
Neurotransmitter Agents
Neurotransmitter Agents
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