J Korean Soc Hypertens.  2013 Sep;19(3):81-89. 10.5646/jksh.2013.19.3.81.

Relation of Inappropriate Left Ventricular Hypertrophy on Framingham Risk Score and Vascular Stiffness in Hypertensive Women

• Kim HM
• Jung JH
• Lee HS
• Kim CH
• Cho GY

• KMID: 1500276
• DOI: http://doi.org/10.5646/jksh.2013.19.3.81

Abstract

BACKGROUND
Although left ventricular hypertrophy (LVH) is a compensatory process to pressure overload, there are gender differences in left ventricular function and vascular stiffness in hypertension. We evaluated that inappropriate LVH was related with Framingham risk score (FRS) and vascular stiffness in hypertensive women.
METHODS
Total 226 hypertensive women consecutively underwent carotid ultrasound and echocardiography, from which LV mass (LVM), carotid intima-media thickness (IMT) and beta-stiffness were measured. Inappropriate LVH was calculated by the ratio of observed LVM to the value predicted for sex, height and stroke work at rest and defined as > 128% of predicted. FRS was obtained using by National Cholesterol Education Program Adult Treatment Panel III.
RESULTS
Of 226 subjects, 59 subjects (26%) had inappropriate LVH. As compared with appropriate LVH, subject with inappropriate LVH showed older age, higher FRS, and IMT. Although LV ejection fraction was not different, diastolic parameters of E/A ratio and left atrial volume were significantly worse in inappropriate LVH group.
CONCLUSIONS
The presence of inappropriate LVH in hypertensive women was strongly associated with higher FRS, decreased diastolic function and increased IMT, which might influence future cardiovascular events.

Keyword

Left ventricular hypertrophy; Vascular stiffness; Hypertension; Women

MeSH Terms

Adult
Carotid Intima-Media Thickness
Echocardiography
Female*
Humans
Hypertension*
Hypertrophy, Left Ventricular*
Ultrasonography
Vascular Stiffness*
Ventricular Function, Left
Cholesterol

Figure

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  Fig. 1. Measurement of carotid intima-media thickness (IMT).

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  Fig. 2. Measurement of luminal strain.

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  Fig. 3. Correlation between left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) and b-stiffness.

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  Fig. 4. Correlation between left ventricular mass (LVM) and Framingham risk score (FRS). LVMI, left ventricular mass index.

Reference

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