Korean J Parasitol.
2013 Apr;51(2):203-206. 10.3347/kjp.2013.51.2.203.
A Fatal Case of Naegleria fowleri Meningoencephalitis in Taiwan
- Affiliations
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- 1Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
- 2Department of Medical laboratory and Biotechnolgy, Chung Shan Medical University, Taichung, Taiwan.
- 3Department of Parasitology, Chung Shan Medical University, Taichung, Taiwan. shih@csmu.edu.tw
- 4Center for Research and Diagnostics, Centers for Disease Control, Taipei, Taiwan.
- 5Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
- 6Department of Tropical Medicine, National Yang-Ming University, Taipei, Taiwan.
- KMID: 1499699
- DOI: http://doi.org/10.3347/kjp.2013.51.2.203
Abstract
- After bathing at a hot spring resort, a 75-year-old man presented to the emergency department because of seizure-like attack with loss of conscious. This is the first case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in Taiwan. PAM was diagnosed based on detection of actively motile trophozoites in cerebrospinal fluid using a wet-mount smear and the Liu's stain. The amoebae were further confirmed by PCR and gene sequencing. In spite of administering amphotericin B treatment, the patient died 25 days later.
MeSH Terms
-
Aged
Amebiasis/*diagnosis/parasitology/*pathology
Central Nervous System Protozoal Infections/*diagnosis/parasitology/*pathology
Cerebrospinal Fluid/parasitology
DNA, Protozoan/chemistry/genetics
Fatal Outcome
Humans
Male
Microscopy
Naegleria fowleri/classification/genetics/*isolation & purification
Polymerase Chain Reaction
Sequence Analysis, DNA
Taiwan
DNA, Protozoan
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