Yonsei Med J.
2023 Oct;64(10):641-645. 10.3349/ymj.2023.0189.
Fatal Primary Amebic Meningoencephalitis due to Naegleria fowleri: The First Imported Case in Korea
- Affiliations
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- 1Division of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea
- 2Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea
- 3Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea
- 4Division of Vectors and Parasitic Diseases, Korea Disease Control and Prevention Agency, Cheongju, Korea
- KMID: 2546252
- DOI: http://doi.org/10.3349/ymj.2023.0189
Abstract
- Primary amebic meningoencephalitis (PAM) is a rare, but almost always fatal, central nervous system infection caused by Naegleria fowleri, which are thermophilic free-living amoeba. Here, we report the first case of PAM detected in South Korea, probably imported from Thailand. Despite antimicrobial treatment for N. fowleri infection with a combination of intravenous liposomal amphotericin B, fluconazole, azithromycin, and oral rifampin, the patient died 13 days after the onset of symptoms. Clinicians in South Korea treating severe meningoencephalitis, especially in individuals returning from tropical areas, are encouraged to include PAM in the differential diagnoses, given the accelerated global warming and increased overseas trips.
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