J Biomed Res.  2013 Jun;14(2):105-110.

Effects of genetic polymorphisms of apolipoprotein A1 on serum HDL cholesterol level in postmenopausal Korean women

• Eom SY
• Kim YD
• Kim H
• Hong JS

Abstract

Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) cholesterol in blood, and ApoA1 genetic polymorphisms modulate the blood lipid profiles. This study was conducted in order to investigate the association between three genetic polymorphisms (rs670, rs5069, and rs5070) of ApoA1 and blood lipid profiles in postmenopausal Korean women. A total of 130 postmenopausal women who visited a hospital in order to undergo screening tests were subjects of this study. Genetic polymporphisms and blood lipid profiles were determined using a direct sequencing and spectrophotometric assay, respectively. A significant linkage disequilibrium was observed between all tested single nucleotide polymorphisms. ApoA1 rs5070 genetic polymorphism showed a marginally significant association with HDL cholesterol levels (p=0.066). After adjusting for age, body mass index, smoking, alcohol drinking, medication, hypertension, and diabetes mellitus, we found that the ApoA1 rs5070 genetic polymorphism is a significant determinant of HDL cholesterol levels (beta=4.421, p=0.037). According to the results of this study, ApoA1 rs5070 genetic polymorphism may be an important genetic marker associated with HDL cholesterol in postmenopausal Korean women.

Keyword

apolipoprotein A1; genetic polymorphism; high density lipoprotein cholesterol

MeSH Terms

Alcohol Drinking
Apolipoprotein A-I*
Apolipoproteins*
Body Mass Index
Cholesterol
Cholesterol, HDL*
Diabetes Mellitus
Female
Genetic Markers
Humans
Hypertension
Linkage Disequilibrium
Lipoproteins
Mass Screening
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Smoke
Smoking
Apolipoprotein A-I
Apolipoproteins
Cholesterol
Cholesterol, HDL
Genetic Markers
Lipoproteins
Smoke