Pediatr Allergy Respir Dis.
2010 Jun;20(2):138-142.
Acute Lupus Pneumonitis as Initial Manifestation of Systemic Lupus Erythematosus
- Affiliations
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- 1Department of Pediatrics, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. pedsyh@gillhospital.com
- 2Department of Radiology, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea.
- 3Department of Pathology, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea.
Abstract
- We report case of a 14-year-old girl with systemic lupus erythematosus who initially presented with acute lupus pneumonitis. She had a 4-week history of exertion for the past 4 weeks, and was transferred from a regional hospital due to abnormality on chest radiographs. Chest radiographs revealed bilateral infiltration and pleural effusion on both lower lung fields. We assumed her to be infected and prescribed antibiotics. The response to antibiotics was ineffective, and viral, bacterial, and mycobacterial cultures were negative. Antinuclear and anti-dsDNA antibodies in serum were positive. The open lung biopsy revealed diffuse alveolar damage. She was diagnosed as having acute lupus pneumonitis in systemic lupus erythematosus and recovered gradually after receiving corticosteroids. Acute lupus pneumonitis may be considered even though interstitial lung involvement in systemic lupus erythematosus is relatively rare in pediatric practice and its diagnosis is difficult.
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