Korean J Hematol.  2008 Dec;43(4):272-275. 10.5045/kjh.2008.43.4.272.

A Case of Granulocytic Sarcoma in the Brain of a Patient with Acute Erythroleukemia

• Cheong JH
• Kwon BR
• Kim MR
• Song MG
• Seol YM
• Choi YJ
• Shin HJ
• Chung JS
• Cho GJ

• KMID: 1485088
• DOI: http://doi.org/10.5045/kjh.2008.43.4.272

Abstract

Granulocytic sarcoma is a localized tumor that's composed of immature granulocytic cells and this is more common in patient with 8;21 translocation. We present here a case in a 64-year-old man who was diagnosed with acute myelogenous leukemia (erythroleukemia) that had a complex hyperdiploid karyotype. While he underwent chemotherapy, he developed nausea, vomiting, headache and dysarthria. After several diagnostic work-ups, granulocytic sarcoma in the cerebellum and leptomeningeal metastasis of his leukemia were found on the magnetic resonance imaging and the cerebrospinal fluid cytology.

Keyword

Leukemia; Erythroblastic; Acute; Sarcoma; Myeloid; Brain

MeSH Terms

Brain
Cerebellum
Dysarthria
Headache
Humans
Karyotype
Leukemia
Leukemia, Erythroblastic, Acute
Leukemia, Myeloid, Acute
Magnetic Resonance Imaging
Middle Aged
Nausea
Neoplasm Metastasis
Sarcoma
Sarcoma, Myeloid
Vomiting
Leukemia, Erythroblastic, Acute

Figure

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  Fig. 1 The touch preparation of bone marrow biopsy demonstrating moderately hypercellular marrow with marked proliferation of severe dysplastic erythroid precursors (80% of all nucleated cells) and blasts. (Wright-Giemsa stain, 1,000×, adapted from Department of Laboratory Medicine, Pusan National University Hospital).

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  Fig. 2 Dysplastic erythroid precursors are Periodic Acid Schiff (PAS) stain positive. (1,000×, adapted from Department of Laboratory Medicine, Pusan National University Hospital).

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  Fig. 3 Magnetic resonance imaging shows mass lesion in left cerebellum which shows high signal intensity on T1-weighted image and low signal intensity on T2-weighted image.

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