Tuberc Respir Dis.  2008 Mar;64(3):187-193. 10.4046/trd.2008.64.3.187.

Trend of Multidrug and Extensively Drug Resistant Tuberculosis in a Tuberculosis Referral Hospital, 2001~2005

• Jeon D
• Shin D
• Kang H
• Sung N
• Kweon K
• Shin E
• Kim K
• Lee M
• Park S

• KMID: 1478179
• DOI: http://doi.org/10.4046/trd.2008.64.3.187

Abstract

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) are serious threats to worldwide tuberculosis control, but the national burden and the trends of infectious spread are largely unknown.
METHODS
We retrospectively reviewed the results of drug sensitivity tests and medical records of patients that were diagnosed with culture-confirmed pulmonary tuberculosis and were admitted to the National Masan Tuberculosis Hospital between 2001 and 2005.
RESULTS
From 2001 to 2005, the proportion of MDR-TB among new cases was 9.2%, 13.8%, 16.9%, 23% and 27.0% in 2001, 2002, 2003, 2004 and 2005, respectively, and the proportion of MDR-TB among previously treated cases was 58.5%, 60.2%, 62.7%, 61.7% and 71.3% in 2001, 2002, 2003, 2004 and 2005, respectively. A significant increasing trend could be discerned for MDR-TB among both new and previously treated cases (p<0.001, p=0.002 for trend, respectively). The proportion of XDR-TB among new cases was 0%, 2.3%, 3.1%, 2.5% and 6.3% in 2001, 2002, 2003, 2004 and 2005, respectively, and the proportion of XDR-TB among previously treated cases was 9.1%, 15.7%, 17.3%, 19.9% and 19.1% in 2001, 2002, 2003, 2004 and 2005, respectively. A significant increasing trend could be discerned for XDR-TB among both new and previously treated cases (p=0.005, p<0.001 for trend, respectively).
CONCLUSION
Both MDR-B and XDR-TB were gradually increased among both new and previously treated cases. Integrated national surveillance, including the public and private sectors, will be needed to estimate the exact status of antituberculous drug resistance.

Keyword

Tuberculosis; Multidrug resistance; Extensively drug-resistant tuberculosis

MeSH Terms

Drug Resistance
Drug Resistance, Multiple
Extensively Drug-Resistant Tuberculosis
Hospitals, Chronic Disease
Humans
Medical Records
Nitroimidazoles
Private Sector
Referral and Consultation
Retrospective Studies
Sulfonamides
Tuberculosis
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary
Nitroimidazoles
Sulfonamides

Figure

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  Figure 1 Trend of multi-drug resistant tuberculosis, 2001~2005.

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  Figure 2 Trend of extensively resistant tuberculosis, 2001~2005.

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