J Korean Neurosurg Soc.  2008 Dec;44(6):401-404. 10.3340/jkns.2008.44.6.401.

Primary Intracranial Squamous Cell Carcinoma in the Brain Stem with a Cerebellopontine Angle Epidermoid Cyst

• Kim MS
• Kim OL

• KMID: 1477505
• DOI: http://doi.org/10.3340/jkns.2008.44.6.401

Abstract

Primary intracranial squamous cell carcinoma is extremely rare, with most cases arising from a preexisting benign epidermoid cyst. We report a rare case of primary intracranial squamous cell carcinoma in the brain stem with a cerebellopontine angle (CPA) epidermoid cyst. A 72-year-old female suffered from progressive left hemiparesis, difficulty in swallowing, and right hemifacial numbness. Diffusion-weighted magnetic resonance imaging revealed a high signal intensity (SI) lesion in the CPA region and an intra-axially ring-enhanced cystic mass in the right brain stem with low SI. Whole-body positron emission tomography showed no evidence of metastatic disease. The histological findings revealed a typical epidermoid cyst in the CPA region and a squamous cell carcinoma in the brain stem. We speculate that the squamous cell carcinoma may have been developed due to a chronic inflammatory response by the adjacent epidermoid cyst. The patient underwent a surgical resection and radiotherapy. After 12 months, she had no evidence of recurrence.

Keyword

Squamous cell carcinoma; Epidermoid cyst; Brain stem; Cerebellopontine angle

MeSH Terms

Aged
Brain
Brain Stem
Carcinoma, Squamous Cell
Cerebellopontine Angle
Deglutition
Epidermal Cyst
Female
Humans
Hypesthesia
Magnetic Resonance Imaging
Paresis
Positron-Emission Tomography
Recurrence