Korean J Obstet Gynecol.  2009 Aug;52(8):835-842.

Relationship between metabolic syndrome and bone mineral density in the postmenopausal women

• Lee SW
• Kim MR
• Kwon DJ
• Kim JH
• Kim JH
• You YO

Abstract

OBJECTIVE
Observational studies suggest that osteoporosis is associated with cardiovascular disease, although another study found that metabolic syndrome (MS) has protective effects on bone. Therefore, this study examined the relationship between metabolic syndrome and bone mineral density (BMD) in postmenopausal women.
METHODS
We divided postmenopausal women who visited St. Vincent Hospital of the Catholic University of Korea in 2006 and 2007 into groups with and without MS and measured their body mass index (BMI), waist-hip ratio (WHR), blood pressure, serum fasting glucose, lipid profile, and BMD of the lumbar spine and femoral neck.
RESULTS
Of the 151 subjects, 66 (43%) had MS and 85 (57%) did not. The women with MS had a higher BMD at the lumbar spine and femoral neck, although after adjusting for age and BMI, this correlation was lost. Significant positive correlations were observed between BMD of the lumbar spine and both high-density lipoprotein (HDL) cholesterol and serum fasting glucose, and BMD of the femoral neck was positively correlated with serum fasting glucose level. The components of MS were not correlated with BMD in these postmenopausal women after adjusting for age and BMI.
CONCLUSION
In our study, the higher BMD in MS was explained by the higher BMI in postmenopausal women. After adjusting for age and BMI, however, MS had no protective effect on bone mass. MS may be another risk factor for postmenopausal osteoporosis.

Keyword

Metabolic syndrome; Bone mineral density; Postmenopause; Body mass index

MeSH Terms

Blood Pressure
Body Mass Index
Bone Density
Cardiovascular Diseases
Cholesterol
Fasting
Female
Femur Neck
Glucose
Humans
Korea
Lipoproteins
Osteoporosis
Osteoporosis, Postmenopausal
Postmenopause
Risk Factors
Spine
Waist-Hip Ratio
Cholesterol
Glucose
Lipoproteins