Korean J Pathol.  2009 Oct;43(5):441-447. 10.4132/KoreanJPathol.2009.43.5.441.

Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women

• Choi G
• Kim JW
• Khang SK
• Kim KR

• KMID: 1472623
• DOI: http://doi.org/10.4132/KoreanJPathol.2009.43.5.441

Abstract

BACKGROUND
Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed.
METHODS
We investigated clinicopathologic characteristics of endometrial carcinoma in 48 women who were under the age of 40 in order to determine treatment guideline.
RESULTS
According To The Criteria Of The Korean Society For Obesity, 70.8% Of Study Patients Were Overweight Or Obese, With An Average Body Mass Index (Bmi) Of 26.0 kg/m2. Twelve Patients Received Progesterone Treatment Only, And 6 Of Them Later Had Successful Pregnancies. The Histologic Subtype Was Endometrioid Adenocarcinoma In All Patients. Figo Stages Were 1A(41.7%), 1B(47.1%), II (2.8%), IIB2.8%), IIIA(2.8%), And IIIC (2.8%). Figo Grades Were Grade 1 (79%) Or 2 (21%). The Average Depth Of Invasion, Excluding Stage 1a, Was 4.6 Mm In The Hysterectomy Specimens. Two Patients Were Given Post-operative Radiation Treatment And 4 Were Treated With Chemotherapy. All But One Case Had An Uneventful Postoperative Course During Follow-up.
CONCLUSIONS
A majority of endometrial carcinomas in young Korean women were associated with an early FIGO stage, favorable histologic subtype and grades, and a good prognosis. Progesterone treatment with close observation was a successful treatment option in a selected group of young patients.

Keyword

Carcinoma; Endometrium; Young age; Progesterone therapy; Pregnancy

MeSH Terms

Adenocarcinoma
Body Mass Index
Carcinoma, Endometrioid
Endometrial Neoplasms
Endometrium
Female
Humans
Hysterectomy
Incidence
Obesity
Overweight
Pregnancy
Progesterone
Prognosis
Progesterone