A Case of Pseudolymphoma Syndrome Induced by Vancomycin

Kim, Sang Tae; Baek, Jae Woo; Kim, Tae Kwon; Lee, Jin Woo; Roh, Hyo Jin; Suh, Kee Suck; Jeon, Young Seung

Abstract

We report here on a case of a patient who experienced fever, skin eruption and lymphadenopathy 1 month after the beginning of vancomycin treatment. Generalized mild pruritic erythematous pin-head to rice-grain sized confluent scaly papules and plaques appeared on the whole body. Skin biopy showed the characteristic findings of pseudolymphoma mimicking mycosis fungoides. The skin lesions and general symptoms improved after discontinuation of vancomycin and starting steroid therapy. The patient was diagnosed with pseudolymphoma syndrome due to vancomycin. Pseudolymphoma syndrome shows clinical features that are different from those of usual drug eruptions, and the histologic findings are similar to mycosis fungoides. Thus, a thorough understanding of the clinical and histologic features of this entity may aid making a diagnosis, establishing treatment plans and determining the prognosis.