Korean J Nephrol.
2009 Mar;28(2):161-165.
A Case of a Kidney Transplant Recipient with Pulmonary Cytomegalovirus and Nocardia Coinfection with Cytomegalovirus Nephropathy
- Affiliations
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- 1Department of Nephrology, Ajou University School of Medicine, Suwon, Korea. gtshin@ajou.ac.kr
- 2Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
- 3Department of Pulmonary and critical Care Medicine, Ajou University School of Medicine, Suwon, Korea.
Abstract
- This is the first reported case of a kidney transplant patient in Korea who developed cytomegalovirus and Nocardia pulmonary coinfection simultaneously with cytomegalovirus nephropathy. The patient had a history of end stage renal disease on peritoneal dialysis, diabetes mellitus and pulmonary tuberculosis. He underwent unrelated living kidney transplantation in China. About 5 months after transplantation, he developed high fever and rising serum creatinine for which he was admitted to hospital. Chest CT revealed consolidation in the left upper lung field and lung biopsy showed CMV infected bronchiolitis obliterans with organizing pneumonia. Culture of lung biopsy tissue grew Nocardia farcinica. In addition, he was found to have CMV infection in kidney tissue with positive CMV antigen assay of blood. This case emphasizes that CMV infection, through its effect on systemic immunity, may increase the risk of other opportunistic infection.
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