J Korean Surg Soc.  2009 Dec;77(Suppl):S1-S4. 10.4174/jkss.2009.77.Suppl.S1.

Inflammatory Myofibroblastic Tumor of the Breast

• Lee BK
• Youn HJ
• Jung SH

• KMID: 1464787
• DOI: http://doi.org/10.4174/jkss.2009.77.Suppl.S1

Abstract

Inflammatory myofibroblastic tumor (IMT) is an uncommon tumor which is composed of spindle cells admixed with mature plasma cells and inflammatory cells. IMT is most common in the lungs and in various organs. However, it is very rare in the breast. According to the organ, there are many clinical and histological characteristics. Breast IMT usually shows developed, movable nontender mass. Radiological findings of IMT are similar to primary breast malignancy. For accurate diagnosis, histologic correlation is needed. IMT is a benign lesion and excision is the treatment of choice, but wide local excision and negative resection margin is needed due to its tendency for recurrence. Understanding of the entity and its mimicry can be helpful in avoiding any unnecessary surgical procedures, such as mastectomy with or without lymph node dissection. Herein, the case of a 29-year-old woman found to have IMT of the breast. The patient underwent a wide local excision. The gross, microscopic and immunohistochemical findings were consistent with the diagnosis of IMT of the breast.

Keyword

Breast; Inflammatory myofibroblastic tumor

MeSH Terms

Adult
Breast
Female
Humans
Lung
Lymph Node Excision
Mastectomy
Myofibroblasts
Plasma Cells
Recurrence

Figure

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  Fig. 1 Right breast ultrasonogram: Ultrasonogram demonstrates an ill defined, homogenous, hypoechoic 2 cm sized septated mass in right breast at 12 o'clock.

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  Fig. 2 Microscopic findings of inflammatory myofibroblastic tumor: Ill-defined tumor shows infiltrative proliferation of spindle cells (H&E stain, ×100).

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  Fig. 3 Microscopic findings of inflammatory myofibroblastic tumor: The tumor is composed of spindle cells and inflammatory cells including foamy histiocytes, lymphocytes, and plasma cells (H&E stain, ×400).

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  Fig. 4 Microscopic findings of inflammatory myofibroblastic tumor: The spindle shaped cells show positivity for smooth muscle actin immmunostaining (IHC stain, ×400).

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  Fig. 5 Microscopic findings of inflammatory myofibroblastic tumor: Infiltration of inflammatory cells composed mainly of CD68-posiitve histiocytes (IHC stain, ×400).

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