Electrolyte Blood Press.  2009 Jun;7(1):20-24. 10.5049/EBP.2009.7.1.20.

Role of Pendrin in Acid: base Balance

• Chang JH
• Kim S

• KMID: 1464785
• DOI: http://doi.org/10.5049/EBP.2009.7.1.20

Abstract

Pendrin (SLC26A4) is a Na+-independent Cl-/HCO3- exchanger which is expressed in the apical membranes of type B and non-A, non-B intercalated cells within the distal convoluted tubule, the connecting tubule, and the cortical collecting duct. In those segments it mediates HCO3- secretion and chloride (Cl-) absorption. In mice, no renal abnormalities are observed under basal conditions, and individuals with genetic disruption of the pendrin (SLC26A4) gene (Pendred syndrome) have normal acid-base balance. In contrast, there are definite differences under conditions wherein the transporter is stimulated. In animal studies, pendrin (SLC26A4) is upregulated with aldosterone analogues, Cl- restriction, and metabolic alkalosis, and is down-regulated with Cl loading and metabolic acidosis, independently. However, the exact role of pendrin in humans has not been established to date, and further examinations are necessary.

Keyword

pendrin; SLC26A4; acidosis, renal tubular; metabolic alkalosis

MeSH Terms

Absorption
Acid-Base Equilibrium
Acidosis
Acidosis, Renal Tubular
Aldosterone
Alkalosis
Animals
Humans
Membranes
Mice
Aldosterone

Figure

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  Fig. 1 Classification of intercalated cell subtypes. Pendrin is expressed on the apical membranes of type B intercalated cells and non-A, non-B intercalated cells.

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  Fig. 2 Pendrin activity in 4 different levels. Pendrin activity is controlled on at least 4 different levels, including mRNA expression and protein abundance, subcellular localization, and numbers of pendrin expressing non type-A intercalated cells.

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  Fig. 3 Effects of NaHCO3 loading, high chloride loading (NH4Cl, NaCl, and KCl), and chloride depletion (low NaCl, and Furosemide loading) on pendrin expression. Pendrin expression is inversely related to diet-induced changes in urinary chloride excretion independent of the administered cation13).

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