Lab Anim Res.  2010 Mar;26(1):103-108. 10.5625/lar.2010.26.1.103.

Scintigraphic Assessment of Renal Function Using 99mTc-DTPA in Miniature Pigs with Unilateral Ureteral Obstruction

• Kim SE
• Shim KM
• Lee WG
• Choi SH
• Park SH
• Han HJ
• Kang SS

• KMID: 1458947
• DOI: http://doi.org/10.5625/lar.2010.26.1.103

Abstract

This study was performed to investigate the proper method for evaluating renal function in miniature pigs with unilateral ureteral obstruction. Experimental unilateral renal damage was induced after ligation of unilateral right ureter in 3 miniature pigs. On the 3rd post-operative day, scintigraphic images were obtained after 12 mCi of 99mTc-diethylentriamene pertaacetate (DTPA) intravenous injection. Renography showed that radiopharmaceutical uptakes in the right kidney were lower than those of left kidney uptakes as early as at 3 days after surgical operation. The static images of 99mTc-DTPA enabled us to measure the relative renal function in miniature pigs with unilateral ureteral obstruction. In conclusion, renography using 99mTc-DTPA was the useful diagnostic method to evaluate the renal function in miniature pigs.

Keyword

99mTc-diethylentriamene pertaacetate (DTPA); unilateral ureteral obstruction; renogram; miniature pig

MeSH Terms

Injections, Intravenous
Kidney
Ligation
Radioisotope Renography
Swine
Ureter
Ureteral Obstruction

Figure

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  Figure. 1. Dynamic images in a miniature pig with unilateral ureteral obstruction after intravenous injection of 12 mCi of 99mTc-DTPA (Left: normal kidney, Right: kidney with unilateral ureteral obstruction).

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  Figure. 2. Posterior dynamic images of a miniature pig with unilateral ureteral obstruction following injection of 99mTc-DTPA. (A) perfusion phase, (B) excretion phase.

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  Figure. 3. Schematic drawing of region of interest. (A) perfusion phase, (B) excretion phase (Left: normal kidney, Right: kidney with unilateral ureteral obstruction).

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  Figure. 4. 99mTc-DTPA time-activity curves from a miniature pig with unilateral ureteral obstruction (Left: normal kidney, Right: kidney with unilateral ureteral obstruction). (A) perfusion time-activity curve (time: seconds), (B) excretion time-activity curve (time: minutes).

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