J Korean Soc Transplant.  2011 Dec;25(4):239-244. 10.4285/jkstn.2011.25.4.239.

Post-transplantation Osteoporosis

• Lee Y
• Shin CS

• KMID: 1450971
• DOI: http://doi.org/10.4285/jkstn.2011.25.4.239

Abstract

Transplantation has become an established treatment in many end-stage organ diseases and hematologic diseases. The survival rate after transplantation has greatly improved due to the development of newer immunosuppressive drugs bringing the issues of post-transplantation complications to light. Osteoporosis and osteoporosis-related fragility fractures are feared complications, greatly influencing the quality of life in transplant patients. In addition to the conventional risk factors for osteoporosis, post-transplantation osteoporosis is caused by factors related to end-stage organ disease prior to transplantation and immunosuppressive therapy after transplantation. Since the rate of bone loss in post-transplantation osteoporosis is thought to be at the greatest immediately following transplantation, early measures need to be taken to prevent and treat post-transplantation osteoporosis. Both conventional and newer therapeutics for osteoporosis are largely being studied and used in practice for the prevention and treatment of post-transplantation osteoporosis.

Keyword

Transplantation; Osteoporosis; Glucocorticoid; Calcineurin inhibitor; Cyclosporine; Tacrolimus

MeSH Terms

Cyclosporine
Hematologic Diseases
Humans
Light
Osteoporosis
Quality of Life
Risk Factors
Survival Rate
Tacrolimus
Transplants
Cyclosporine
Tacrolimus

Figure

• 

  Fig. 1. Mechanisms of post-transplant bone loss. (A) Early post-transplant bone loss, (B) late post-transplant bone loss. Adapted from Fig. 1 of reference [33].

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