J Korean Assoc Oral Maxillofac Surg.  2011 Aug;37(4):295-300. 10.5125/jkaoms.2011.37.4.295.

Experimental study about the bony healing of hydroxyapatite coating implants

• Eom TG
• Kim JH
• Cho IH
• Jeong CM
• Cho YS
• Kim YK

• KMID: 1449062
• DOI: http://doi.org/10.5125/jkaoms.2011.37.4.295

Abstract

INTRODUCTION
Hydroxyapatite(HA) coating implant can accelerate osseointegration, however, there are many controversies.
MATERIALS AND METHODS
This study examined the early osseointegration of two types of hydroxyapatite coated implants. Twelve adult male miniature pigs (Medi Kinetics Micropigs, Medi Kinetics Co., Ltd., Busan, Korea) were used in this study. In the implants placed in the mandible, a histomorphometric evaluation was performed to evaluate the bone-implant contact (BIC) ratio.
RESULTS
The BIC ratio increased with time. TS III HA and Zimmer HA were not significantly different (P>0.05). At 8 weeks, the BIC of Zimmer HA was higher than TS III HA, but there was no significant difference (P>0.05).
CONCLUSION
HA coated implants will accelerate early osseointegration.

Keyword

Bone-implant contact; Hydroxyapatite coated implant

MeSH Terms

Adult
Durapatite
Humans
Kinetics
Male
Mandible
Nitrogen Mustard Compounds
Osseointegration
Swine
Durapatite
Nitrogen Mustard Compounds

Figure

• 

  Fig. 1. TS III HA and Zimmer HA.

• 

  Fig. 2. Bone-implant contact measuring area.

• 

  Fig. 3. Bone-implant contact measuring method.

• 

  Fig. 4. Histological finding of TS III HA after 2 weeks. New bones grew from the cutting line of the host bone to contact the screw threads directly, which was superior to the two other surfaces.(H&E stain, ×100)

• 

  Fig. 5. Histological finding of TS III HA after 4 weeks. The thickness of the newly formed trabecular bones increased, and bone remodeling was ongoing.(H&E stain, ×100)

• 

  Fig. 6. Histological finding of TS III HA after 8 weeks. Lamellar structures formed by the apposition of new bones were observed, and bone remodeling was ongoing.(H&E stain, ×100)

• 

  Fig. 7. Histological finding of Zimmer HA after 2 weeks was similar with that of TS III HA.

• 

  Fig. 8. Histological finding of Zimmer HA after 4 weeks was similar with that of TS III HA.

• 

  Fig. 9. Histological finding of Zimmer HA after 8 weeks was similar with that of TS III HA. Bone-implant contact ratio of Zimmer was higher than TS III HA, however, there was no statistically significant difference.

• 

  Fig. 10. Bone-implant contact ratio of TS III HA and Zimmer implant.

Reference

1. Jeong R, Marin C, Granato R, Suzuki M, Gil JN, Granjeiro JM, et al. Early bone healing around implant surfaces treated with variations in the resorbable blasting media method. A study in rabbits. Med Oral Patol Oral Cir Bucal. 2010; 15(1):e119–25.

2. Abdel-Haq J, Karabuda CZ, Arısan V, Mutlu Z, Körkçö M. Osseointegration and stability of a modified sand-blasted acid-etched implant: an experimental pilot study in sheep. Clin Oral Implants. 2011; 22:265–74.

3. Zhu X, Ong JL, Kim S, Kim K. Surface characteristics and structure of anodic oxide films containing Ca and P on a titanium implant material. J Biomed Mater Res. 2002; 60:333–8.

4. Whitehead RY, Lucas LC, Lacefield WR. The effect of dissolution on plasma sprayed hydroxylapatite coatings on titanium. Clin Mater. 1993; 12:31–9.

5. Wheeler SL. Eight-year clinical retrospective study of titanium plasma-sprayed and hydroxyapatite-coated cylinder implants. Int J Oral Maxillofac Implants. 1996; 11:340–50.

6. Trisi P, Keith DJ, Rocco S. Human histologic and histomorphometric analyses of hydroxyapatite-coated implants after 10 years of unction: a case report. Int J Oral Maxillofac Implants. 2005; 20:124–30.

7. McGlumphy EA, Peterson LJ, Larsen PE, Jeffcoat MK. Prospective study of 429 hydroxyapatite-coated cylindric om-niloc implants placed in 121 patients. Int J Oral Maxillofac Implants. 2003; 18:82–92.

8. Lee JJ, Rouhfar L, Beirne OR. Survival of hydroxyapatite-coated implants: a meta-analytic review. J Oral Maxillofac Surg. 2000; 58:1372–9.

9. Morris HF, Ochi S. Hydroxyapatite-coated implants: a case for their use. J Oral Maxillofac Surg. 1998; 56:1303–11.

10. Chang YL, Lew D, Park JB, Keller JC. Biomechanical and morphometric analysis of hydroxyapatite-coated implants with varying crystallinity. J Oral Maxillofac Surg. 1999; 57:1096–108.

11. Kim H, Choi SH, Chung SM, Li LH, Lee IS. Enhanced bone forming ability of SLA-treated Ti coated with a calcium phosphate thin film formed by e-beam evaporation. Biomed Mater. 2010; 5:044106.

12. Rohner D, Tay A, Chung SM, Hutmacher DW. Interface of unloaded titanium implants in the iliac crest, fibula, and scapula: a histomorphometric and biomechanical study in the pig. Int J Oral Maxillofac Implants. 2004; 19:52–8.

13. Choi JY, Jung UW, Lee IS, Kim CS, Lee YK, Choi SH. Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study. Clin Oral Implants Res. 2011; 22:343–8.

14. Thierer T, Davliakos JP, Keith JD Jr, Sanders JJ, Tarnow DP, Rivers JA. Five-year prospective clinical evaluation of highly crystalline HA MP-1-coated dental implants. J Oral Implantol. 2008; 34:39–46.

15. Artzi Z, Carmeli G, Kozlovsky A. A distinguishable observation between survival and success rate outcome of hydroxyapatite-coated implants in 5-10 years in function. Clin Oral Implants Res. 2006; 17:85–93.

16. Osstem Implant Co. TS III HA implant system clinical monitoring. 2010. 1–36. Busan.

17. Cook SD, Key JF, Thomas KA, Jarcho M. Interface mechanics and histology of titanium and hydroxylapatite-coated titanium for dental implant applications. Int J Oral Maxillofac Implants. 1987; 2:15–22.

18. Block MS, Kent JN, Kay JF. Evaluation of hydroxylapatite-coated titanium dental implants in dogs. J Oral Maxillofac Surg. 1987; 45:601–7.

19. Baker D, London RM, O’ Neal R. Rate of pull-out strength gain of dual-etched titanium implants: a comparative study in rabbits. Int J Oral Maxillofac Implants. 1999; 14:722–8.

20. Friberg B, Sennerby L, Linden B, Grondahl K, Lekholm U. Stability measurements of one-stage Brånemark implants during healing in mandibles. A clinical resonance frequency analysis study. Int J Oral Maxillofac Surg. 1999; 28:266–72.

21. Noguerol B, Mun ̃oz R, Mesa F, de Dios Luna J, O’ Valle F. Early implant failure. Prognostic capacity of Periotest: retrospective study of a large sample. Clin Oral Implants Res. 2006; 17:459–64.

22. Masuda T, Yliheikkilä PK, Felton DA, Cooper LF. Generalizations regarding the process and phenomenon of osseointegration. Part I. In vivo studies. Int J Oral Maxillofac Implants. 1998; 13:17–29.

23. Nkenke E, Fenner M, Vairaktaris EG, Neukam FW, Radespiel-Tröger M. Immediate versus delayed loading of dental implants in the maxillae of minipigs. Part II: histomorphometric analysis. Int J Oral Maxillofac Implants. 2005; 20:540–6.