Korean J Obstet Gynecol.  2011 Dec;54(12):817-819. 10.5468/KJOG.2011.54.12.817.

Schwannoma of the clitoris: A case report

• Yu YS
• Kwon DY
• Park JM
• Choi SC
• Ryu SY

• KMID: 1443949
• DOI: http://doi.org/10.5468/KJOG.2011.54.12.817

Abstract

Schwannomas arise from schwann cells in the peripheral nerve sheath, without involving the nerve fibers. Schwannomas are benign, slow-growing tumors that infrequently recur and rarely undergo malignant change. Also schwannomas of the female genitalia are considered extremely rare. We report a case of schwannoma of the clitoris. A 76-year-old woman without neurofibromatosis presented with a 2.0 x 1.7 cm, painless mass of the clitoris. Simple surgical excision of the mass was undertaken, and final pathology revealed schwannoma of the clitoris. No evidence of local recurrence was noted after 1 year of follow-up.

Keyword

Schwannoma; Clitoris

MeSH Terms

Aged
Clitoris
Female
Follow-Up Studies
Genitalia, Female
Humans
Nerve Fibers
Neurilemmoma
Neurofibromatoses
Peripheral Nerves
Recurrence
Schwann Cells

Figure

• 

  Fig. 1 Gross feature of specimen. Figure shows a 2.0 × 1.7 × 1.5 cm sized mass. Cut surface is well demarcated, encapsulated and yellowish myxoid.

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  Fig. 2 Pathologic findings of specimen. Light microscopic appearance of tumor shows proliferation of many spindle cells with whorling pattern (H&E, ×200).

Reference

1. Obeidat BR, Amarin ZO, Jallad MF. Vaginal schwannoma: a case report. J Reprod Med. 2007. 52:341–342.

2. Yamashita Y, Yamada T, Ueki K, Ueki M, Sugimoto O. A case of vulvar schwannoma. J Obstet Gynaecol Res. 1996. 22:31–34.

3. Cheng WC. Nerve tumour of the clitoris. Report of a case and commentary. J Obstet Gynaecol Br Commonw. 1966. 73:1016–1017.

4. Huang HJ, Yamabe T, Tagawa H. A solitary neurilemmoma of the clitoris. Gynecol Oncol. 1983. 15:103–110.

5. Llaneza P, Fresno F, Ferrer J. Schwannoma of the clitoris. Acta Obstet Gynecol Scand. 2002. 81:471–472.

6. Kao GF, Laskin WB, Olsen TG. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Mod Pathol. 1989. 2:20–26.

7. Enzinger FM, Weiss SW. Enzinger FM, editor. Benign tumors of peripheral nerves. Soft tissue tumors. 1995. 3rd ed. St Louis: Mosby;821–863.

8. Scheithauer BW, Woodruff JM, Erlandson RA. Scheithauer BW, Woodruff JM, Erlandson RA, editors. Schwannoma. Tumors of the eripheral nervous system. Atlas of tumor pathology. 3rd series, Fascicle 24. 1997. Washington: Armed Forces Institute of Pathology;105–156. 177–218.

9. Fletcher CD, Davies SE. Benign plexiform (multinodular) schwannoma: a rare tumour unassociated with neurofibromatosis. Histopathology. 1986. 10:971–980.

10. Fletcher CD. Rosen PP, Fechner RE, editors. Peripheral nerve sheath tumors: a clinicopathologic update. Pathology annual. Part 1. 1990. Norwalk: Appleton and Lange;51–74.

11. Woodruff JM, Selig AM, Crowley K, Allen PW. Schwannoma (neurilemoma) with malignant transformation. A rare, distinctive peripheral nerve tumor. Am J Surg Pathol. 1994. 18:882–895.

12. Weiss SW, Goldblum JR. Weiss SW, Goldblum JR, editors. Benign tumors of peripheral nerves. Enzinger and Weiss's soft tissue tumors. 2001. 4ed. St. Louis: Mosby;1111–1208.

13. Yüksel H, Odabaşi AR, Kafkas S, Onur E, Turgut M. Clitoromegaly in type 2 neurofibromatosis: a case report and review of the literature. Eur J Gynaecol Oncol. 2003. 24:447–451.

14. Chuang WY, Yeh CJ, Jung SM, Hsueh S. Plexiform schwannoma of the clitoris. APMIS. 2007. 115:889–890.