J Korean Soc Radiol.  2011 Jun;64(6):611-614. 10.3348/jksr.2011.64.6.611.

Abdominal Wall Metastasis from an Invasive Lobular Carcinoma of the Breast: A Case Report

• Kim H
• Son EJ
• Noh SM
• Jung WH
• Youk JH
• Chung J

• KMID: 1443513
• DOI: http://doi.org/10.3348/jksr.2011.64.6.611

Abstract

Breast cancer is one of the most common malignancies in women. Breast cancer frequently metastasizes to the bones, lungs, and liver. However, the recurrence of distant soft-tissue metastasis except to the chest wall is extremely rare. Here, we describe our experience with a patient in whom invasive lobular carcinoma of the breast with metastasis to the abdominal wall presented as subcutaneous nodules without local recurrence.

MeSH Terms

Abdominal Wall
Breast
Breast Neoplasms
Carcinoma, Lobular
Female
Humans
Liver
Lung
Neoplasm Metastasis
Recurrence
Thoracic Wall

Figure

• 

  Fig. 1 A 64-year-old woman with a right partial mastectomy performed 3 year ago. A. US image demonstrates a lobulated heterogeneous echoic mass measuring about 2.0×1.4 cm in the subcutaneous layer of the right lower abdominal wall (white arrows). B. Another 1.1 cm large hyperechoic nodule at the mid abdominal wall is seen (white arrows).

• 

  Fig. 2 PET-CT scan of the patient. A. Increased FDG uptake along the abdominal wall which corresponds to the 2.0 cm sized nodule on CT scan and noted on US image (white arrow) B. Another FDG uptake lesion is noted at the mid abdominal wall corresponding to the 1.1 cm sized round nodule on CT scan (white arrow).

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  Fig. 3 Photomicrograph of the core biopsy specimen (×100). A photomicrograph of a histologic specimen from abdominal wall mass shows isolated cells and small cords of cells an "Indian file" pattern (arrow) that is characteristic of lobular carcinoma and diffusely infiltrating skeletal muscle fibers (arrowhead) (H and E, × 100).

Reference

1. Sastre-Garau X, Jouve M, Asselain B, Vincent-Salomon A, Beuzeboc P, Dorval T, et al. Infiltrating lobular carcinoma of the breast: clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns. Cancer. 1996; 77:113–120.

2. Winston CB, Hadar O, Teitcher JB, Caravelli JF, Sklarin NT, Panicek DM, et al. Metastatic lobular carcinoma of the breast: patterns of spread in the chest, abdomen, and pelvis on CT. AJR Am J Roentgenol. 2000; 175:795–800.

3. Harris M, Howell A, Chrissohou M, Swindell RI, Hudson M, Sellwood RA. A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer. 1984; 50:23–30.

4. Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993; 114:637–641.

5. Lamovec J, Bracko M. Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol. 1991; 48:28–33.

6. Kidney DD, Cohen AJ, Butler J. Abdominal metastases of infiltrating lobular breast carcinoma: CT and fluoroscopic imaging findings. Abdom Imaging. 1997; 22:156–159.

7. El Khoury M, Cherel P, Becette V, De Maulmont C, Costes V, Talma V, et al. Unusual soft-tissue metastasis of an invasive lobular carcinoma mimicking fasciitis. AJR Am J Roentgenol. 2004; 182:745–747.

8. Rasbridge SA, Gillett CE, Sampson SA, Walsh FS, Millis RR. Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. J Pathol. 1993; 169:245–250.

9. Van Aken E, De Wever O, Correia da Rocha AS, Mareel M. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 2001; 439:725–751.

10. Ferlicot S, Vincent-Salomon A, Medioni J, Genin P, Rosty C, Sigal-Zafrani B, et al. Wide metastatic spreading in infiltrating lobular carcinoma of the breast. Eur J Cancer. 2004; 40:336–341.