Korean J Gastrointest Endosc.  2011 Jul;43(1):56-59.

Ill-defined Granulomas Demonstrated in Ulcers of the Terminal Ileum and Transverse Colon in a Patient with Typhoid Fever

• Yun SG
• Kim NH
• Kim MH
• Park JH
• Bae WK
• Kim KA
• Lee JS
• Kim HS

Abstract

Typhoid fever, the most serious human salmonellosis, is a systemic infectious disease caused by Salmonella enterica serovar Typhi and is characterized by prolonged fever, bacteremia, and multiplication of the organism within mononuclear phagocytic cells of the liver, spleen, lymph nodes, and Peyer's patches. The characteristic lesion of typhoid fever is an ulceration of the small intestinal lymphoid tissue, particularly the Peyer's patches. The usual histological findings of typhoid ulcer are necrosis and histiocytic proliferation that phagocytizes erythrocytes and degenerated lymphocytes. A granuloma is an unusual histopathological presentation of a typhoid lesion. Even if granulomas have been reported in the bone marrow, liver, and spleen in cases of typhoid fever, granulomas in primary ulcers of the ileum and transverse colon have been reported very rarely. We experienced a case of typhoid fever in which ill-defined granulomas were seen in ulcers of the terminal ileum and transverse colon.

Keyword

Salmonella infection; Typhoid fever; Granuloma

MeSH Terms

Bacteremia
Bone Marrow
Colon, Transverse
Communicable Diseases
Erythrocytes
Fever
Granuloma
Humans
Ileum
Liver
Lymph Nodes
Lymphocytes
Lymphoid Tissue
Necrosis
Peyer's Patches
Phagocytes
Salmonella Infections
Salmonella typhi
Spleen
Typhoid Fever
Ulcer