Korean J Pediatr Infect Dis.  2012 Aug;19(2):79-83.

A Case of Reye Syndrome Following Treatment of Kawasaki Disease with Aspirin

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. eunchoi@snu.ac.kr
  • 2Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
  • 3Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

Reye syndrome is a rapidly progressive encephalopathy with hepatic dysfunction, which often begins several days after apparent recovery from a viral illness, especially varicella or influenza A or B. Salicylate use was identified as a major precipitating factor for the development of Reye syndrome. With the recommendation to avoid use of salicylates in children, Reye syndrome has virtually disappeared in recent years. We report a case of Reye syndrome in a 5-month-old infant who had been treated with intravenous immunoglobulin and aspirin under the diagnosis of Kawasaki disease, and showed symptoms of sudden onset of irritability, rigidity, decreased activity, vomiting, poor appetite, lethargy, liver dysfunction without jaundice, coagulopathy, and hyperammonemia.

Keyword

Kawasaki Disease; Reye Syndrome; Aspirin

MeSH Terms

Appetite
Aspirin
Chickenpox
Child
Humans
Hyperammonemia
Immunoglobulins
Infant
Influenza, Human
Jaundice
Lethargy
Liver Diseases
Mucocutaneous Lymph Node Syndrome
Precipitating Factors
Reye Syndrome
Salicylates
Vomiting
Aspirin
Immunoglobulins
Salicylates

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