J Korean Assoc Maxillofac Plast Reconstr Surg.  2012 Jul;34(4):260-266.

Plate and Screw Removal after Orthognathic Surgery, under Intravenous Sedation with Dexmedetomidine and Pethidine

• Kang HJ
• Kim JR
• Kim SY
• Choi TS
• Chang KU

Abstract

PURPOSE
The purpose of this study is to identify the changes of a physiologic nature and the sedative parameters associated with dexmedetomidine and pethidine, in patients undergoing plate and screw removal surgery, after orthognathic surgery.
METHODS
Twenty-three patients were sedated with dexmedetomidine and pethidine during plate and screw removal, after orthognathic surgery. An initial loading dose of dexmedetomidine (1.0 microg/kg infused over 10 minutes) was followed by a maintenance dose (1.0 microg/kg/hr). Systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation, and heart rate were monitored. Perioperative amnesia and anxiety were recorded.
RESULTS
Significant changes were found in the blood pressure and heart rate (Freidman test, P<0.05), but not in oxygen saturation (Freidman test, P>0.05). Amnesia during local injection was observed in eight patients (34.8%). Compared with the preoperative anxiety score, the intraoperative anxiety score was decreased.
CONCLUSION
In this study, we found cardiovascular and respiratory stability in intravenous sedation using dexmedetomidine with pethidine, in plate and screw removal, after orthognathic surgery. Furthemore, intravenous sedation using dexmedetomidine with pethidine shows adequate analgesic and sedative effects.

Keyword

Orthognathic surgery; Dexmedetomidine; Meperidine; Plate and screw removal

MeSH Terms

Amnesia
Anxiety
Arterial Pressure
Blood Pressure
Dexmedetomidine
Heart Rate
Humans
Hypnotics and Sedatives
Meperidine
Orthognathic Surgery
Oxygen
Dexmedetomidine
Hypnotics and Sedatives
Meperidine
Oxygen