Korean J Otorhinolaryngol-Head Neck Surg.  2013 Apr;56(4):185-190. 10.3342/kjorl-hns.2013.56.4.185.

Characterization of Membrane Excitability of Purkinje Cells in Vestibulocerebellum Using Patch Clamp Techniques

• Kim CH

• KMID: 1426491
• DOI: http://doi.org/10.3342/kjorl-hns.2013.56.4.185

Abstract

Cerebellum is known as a center for sensory/motor coordination and memory storage in motor learning. The vestibular nuclei have extensive afferent and efferent connections with posterior cerebellum which can be referred to as vestibulocerebellum. While secondary vestibular afferents are distributed bilaterally in the vestibulocerebellum, primary afferents may directly project to ipsilateral vestibulocerebellum. The Purkinje cells which are the only output neurons from the cerebellar cortex receive vestibular information via parallel and climbing fibers. That information is integrated and encoded in the Purkinje cells and then conveyed into the vestibular nucleus or deep cerebellar nucleus, which permits adaptive guidance of vestibular function by the vestibulocerebellum.

Keyword

Electrophysiology; Patch clamp; Purkinje cell; Vestibulocerebellum

MeSH Terms

Cerebellar Cortex
Cerebellar Nuclei
Cerebellum
Electrophysiology
Learning
Membranes
Memory
Neurons
Patch-Clamp Techniques
Purkinje Cells
Vestibular Nuclei