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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Cordycepin protects against β-amyloid and ibotenic acid-induced hippocampal CA1 pyramidal neuronal hyperactivity

Yao LH, Wang J, Liu C, Wei S, Li G, Wang S, Meng W, Liu ZB, Huang LP

Cordycepin exerts neuroprotective effects against excitotoxic neuronal death. However, its direct electrophysiological evidence in Alzheimer's disease (AD) remains unclear. This study aimed to explore the electrophysiological mechanisms underlying the protective...
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Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice

Nguyen HT, Cho DH, Jang SH, Han SK, Park SJ

The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and...
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The role of calmodulin in regulating calcium-permeable PKD2L1 channel activity

Park EY, Baik JY, Kwak M, So I

Polycystic kidney disease 2-like-1 (PKD2L1), polycystin-L or transient receptor potential polycystin 3 (TRPP3) is a TRP superfamily member. It is a calcium-permeable non-selective cation channel that regulates intracellular calcium concentration...
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Comparison of electrophysiological properties of two types of pre-sympathetic neurons intermingled in the hypothalamic paraventricular nucleus

Shen Y, Han SK, Ryu PD

The hypothalamic paraventricular nucleus (PVN) contains two types of neurons projecting to either the rostral ventrolateral medulla (PVN(RVLM)) or the intermediolateral horn (IML) of the spinal cord (PVN(IML)). These two...
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Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

Lee KY, Jang Y, Lee MH, Kim YI, Jung SC, Han SY, Kim SH, Park HS, Kim DK

OBJECTIVE: Propofol is an intravenously administered anesthetic that enhances γ-aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated...
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Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice

Shen Y, Bhattarai , Park SJ, Lee GS, Ryu PD, Han SK

It has been reported that Korean red ginseng (KRG), a valuable and important traditional medicine, has varied effects on the central nervous system, suggesting its activities are complicated. The paraventricular...
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Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel

Lee HM, Chai OH, Hahn SJ, Choi BH

In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures...
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Passage-dependent expression of inward rectifying potassium current in human umbilical cord vein-derived mesenchymal stem cells

Park KS, Chai YG, Kim Y

Although stem cells are used as important cell therapies in regenerative medicine, the electrophysiological problems that arise in the expansion of cells have not been known much. This study was...
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Acepromazine inhibits hERG potassium ion channels expressed in human embryonic kidney 293 cells

Joo YS, Lee HJ, Choi JS, Sung KW

The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were...
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Type 2 Diabetes Induces Prolonged P-wave Duration without Left Atrial Enlargement

Li B, Pan Y, Li X

Prolonged P-wave duration has been observed in diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the possible mechanisms. A rat model of type...
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Blockade of Kv1.5 channels by the antidepressant drug sertraline

Lee HM, Hahn SJ, Choi BH

Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been reported to lead to cardiac toxicity even at therapeutic doses including sudden cardiac death and ventricular arrhythmia. And in a SSRI-independent...
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Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome

Lee YS, Olaopa MA, Jung BC, Lee SH, Shin DG, Park HS, Cho Y, Han SM, Lee MH, Kim YN

BACKGROUND AND OBJECTIVES: Due to recent studies that have shown an association between the genetic variation of SCN5A and sick sinus syndrome (SSS), we sought to determine if a similar...
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Blockade of Kv1.5 by paroxetine, an antidepressant drug

Lee HM, Hahn SJ, Choi BH

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that...
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Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus

Kim CH, Ko IG, Kim SE, Shin MS, Kang YH, Cho JW, Shin KM, Kim CJ, Lim BV, Kim KH

PURPOSE: Alpha1 (alpha1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the...
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Transient Receptor Potential C4/5 Like Channel Is Involved in Stretch-Induced Spontaneous Uterine Contraction of Pregnant Rat

Chung S, Kim YH, Joeng JH, Ahn DS

Spontaneous myometrial contraction (SMC) in pregnant uterus is greatly related with gestational age and growing in frequency and amplitude toward the end of gestation to initiate labor. But, an accurate...
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Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon

Jiao HY, Kim DH, Ki JS, Ryu KH, Choi S, Jun JY

Lubiprostone is a chloride (Cl-) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal...
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The Protective Effect of Epigallocatechin-3-Gallate Against Gentamicin Vestibular Ototoxicity in Type I Vestibular Hair Cell of Guinea Pig

Choi YH, Lee SS, Moon SJ, Ahn BH, Kim NG, Jeong HS, Park JS, Cho HH, Cho YB

BACKGROUND AND OBJECTIVES: Gentamicin (GM) is well known for its vestibulotoxicity. There have been many reports about vestibulotoxicity, however, its mechanism is still unclear. So far, it is known that...
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The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell

Park KS, Han MH, Jang HK, Kim KA, Cha EJ, Kim WJ, Choi YH, Kim Y

Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium...
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Functional expression of mechanosensitive two-pore domain potassium channel in human bladder carcinoma cells

Park KS, Kim Y

  • KMID: 1498924
  • J Biomed Res.
  • 2013 Jun;14(2):71-76.
Bladder cancer is a common cancer in smoking men and may correlate with mechanosensitive potassium channels because the urinary bladder is a stretch sensing organ. Two-pore K+ channels (K2P), such...
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