J Korean Neurosurg Soc.  2012 Dec;52(6):561-563. 10.3340/jkns.2012.52.6.561.

Desmoplastic Fibroma of the Cranium in a Young Man

• Lee S
• Jung SM
• Cho BK
• Kim H

• KMID: 1426269
• DOI: http://doi.org/10.3340/jkns.2012.52.6.561

Abstract

Desmoplastic fibroma, which develops predominantly in long bones and the mandible, is a rare and benign but locally aggressive tumor. Desmoplastic fibroma of the cranium is extremely rare. We report a case of desmoplastic fibroma of the frontal bone in a young man. Because of its locally aggressive behavior, complete surgical excision with a safety margin is essential.

Keyword

Desmoplastic fibroma; Frontal bone; Skull

MeSH Terms

Fibroma, Desmoplastic
Frontal Bone
Mandible
Skull

Figure

• 

  Fig. 1 A : CT scan demonstrating focal calvarial thickening of right frontal skull. B, C and D : MRI reveals intermediate signal intensity on T1-weighted images and heterogeneous intensity on T2-weighted images with multifocal enhancement.

• 

  Fig. 2 A : Micrograph of the lesion showing spindle cell proliferation with hemorrhage and fat necrosis (H&E, ×100). B : Note fibroblastic proliferation with collagenous background (H&E, ×200). C : Smooth muscle actin staining revealed focal positivity (×200).

Reference

1. Böhm P, Kröber S, Greschniok A, Laniado M, Kaiserling E. Desmoplastic fibroma of the bone. A report of two patients, review of the literature, and therapeutic implications. Cancer. 1996; 78:1011–1023. PMID: 8780539.

2. Brooks MD, Ebbs SR, Colletta AA, Baum M. Desmoid tumours treated with triphenylethylenes. Eur J Cancer. 1992; 28A:1014–1018. PMID: 1385717.

3. Campanacci M. Campanacci M, editor. Desmoid fibroma (desmoplastic fibroma). Bone and Soft Tissue Tumors : Clinical Features, Imaging, Pathology and Treatment. 1999. ed 2nd. Wien: Springer-Verlag;p. 143–148.

4. Chopra R, Bhardwaj M, Premsagar IC. Fibrosarcoma of the meninges. Rare Tumors. 2010; 2:e3. PMID: 21139948.

5. Deniz K, Ceylan D. Desmoplastic fibroma of the skull. Acta Neurochir (Wien). 2008; 150:285–290. PMID: 18193151.

6. Fletcher C, Unni K, Mertens F. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. 2002. ed 3rd. Lyon: IARC Press;p. 289.

7. Gardini G, Minghetti G, Ferracini R. [Desmoplastic fibroma of frontal bone. Report of a case (author's transl)]. Pathologica. 1978; 70:575–579. PMID: 745862.

8. Gebhardt MC, Campbell CJ, Schiller AL, Mankin HJ. Desmoplastic fibroma of bone. A report of eight cases and review of the literature. J Bone Joint Surg Am. 1985; 67:732–747. PMID: 3997926.

9. Goldberg AN, Janecka IP, Sekhar LN. Desmoplastic fibroma of the skull : a case report. Otolaryngol Head Neck Surg. 1995; 112:589–591. PMID: 7700667.

10. Hopkins KM, Huttula CS, Kahn MA, Albright JE. Desmoplastic fibroma of the mandible : review and report of two cases. J Oral Maxillofac Surg. 1996; 54:1249–1254. PMID: 8859247.

11. Hwang SH, Won YS, Yang JY, Choi CS. Desmoplastic Fibroma of the Skull. J Korean Neurosurg Soc. 2007; 41:53–56.

12. Inwards CY, Unni KK, Beabout JW, Sim FH. Desmoplastic fibroma of bone. Cancer. 1991; 68:1978–1983. PMID: 1913545.

13. Jaffe H. Tumors and tumorous conditions of the bones and joints. 1958. Philadelphia: Lea & Febiger.

14. Kim JH, Park JY, Jung YG, Suh JK, Kim SN, Suh YL. Desmoplastic fibroma of the skull; a case report, review of the literature, and therapeutic implications. J Korean Neurosurg Soc. 2001; 30:1037–1041.

15. Kim KS, Noh JS, Chung BS, Shin MK. Desmoplastic fibroma of the skull. J Korean Neurosurg Soc. 2006; 39:393–395.

16. Kransdorf MJ, Berquist TH. Berquist TH, editor. Musculoskeletal neoplasms. MRI of the Musculoskeletal System. 2001. Philadelphia: Lippincott Williams & Wilkins;p. 891–893.

17. Lath R, Ranjan A, Ratnam BG, Gowrishankar S. Desmoplastic fibroma of the frontal bone. Neurol India. 2006; 54:314–315. PMID: 16936402.

18. Rabin D, Ang LC, Megyesi J, Lee DH, Duggal N. Desmoplastic fibroma of the cranium : case report and review of the literature. Neurosurgery. 2003; 52:950–954. discussion 954. PMID: 12657192.