J Korean Med Sci.  1991 Jun;6(2):157-163. 10.3346/jkms.1991.6.2.157.

Malignant glomus tumor originating in the superior mediastinum: an immunohistochemical and ultrastructural study

Affiliations
  • 1Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.

Abstract

An extremely rare case of malignant glomus tumor originating in the superior mediastinum was evaluated immunohistochemically and ultrastructurally. A 78-year-old woman who had been suffering from dysphagia and dyspnea had poorly-defined soft tissue mass, 4.5 x 2.5cm, in the superior mediastinum with direct invasion into the esophagus, trachea, and bilateral thyroid glands. This case is believed to be unique in several respects. There were neither recognizable findings of benign glomus tumor nor sarcomatous areas, in contrast to the previously reported cases. A definite direct invasion into the surrounding organs was identified. We therefore interpreted this case as primary malignant glomus tumor, not as glomangiosarcoma arising in a benign glomus tumor.

Keyword

Malignant glomus tumor; Superior mediastinum; Glomangiosarcoma

MeSH Terms

Actins/metabolism
Aged
Female
Glomus Tumor/metabolism/*pathology/ultrastructure
Humans
Immunohistochemistry
Mediastinal Neoplasms/metabolism/*pathology/ultrastructure
Microscopy, Electron
Myosins/metabolism
Neoplasm Invasiveness
Vimentin/metabolism
Actins
Vimentin
Myosins

Cited by  2 articles

Malignant Glomus Tumor of the Peritoneum: Case Report
Sandra Baleato-González, Roberto García-Figueiras, Maria Virginia Trujillo-Ariza, Juan Jose Carrera-Álvarez
Korean J Radiol. 2014;15(1):61-65.    doi: 10.3348/kjr.2014.15.1.61.

Mediastinal Glomus Tumor: A Case Report and Literature Review
Si-Hyong Jang, Hyun Deuk Cho, Ji-Hye Lee, Hyun Ju Lee, Hae Yoen Jung, Kyung-Ju Kim, Sung Sik Cho, Mee-Hye Oh
J Pathol Transl Med. 2015;49(6):520-524.    doi: 10.4132/jptm.2015.07.02.

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