J Korean Med Sci.  1987 Sep;2(3):151-156. 10.3346/jkms.1987.2.3.151.

Gamma interferon modulates epidermal cell proliferation and mixed epidermal cell-lymphocyte reaction

• Kim SY
• Houh W

• KMID: 1421261
• DOI: http://doi.org/10.3346/jkms.1987.2.3.151

Abstract

Gamma interferon (gamma-IFN), a lymphokine produced by activated T lymphocytes, has a variety of effects on target cell. It induces class II antigens of the major histocompatibility complex not only in immunocompetent cells but also in non-immunocompetent cells. gamma-IFN also can exert, in addition to anti-viral activity, a series of anticellular effects on a variety of cell types. The effects of gamma-IFN on the proliferation of cultured epidermal cell (EC) and induction of HLA-DR antigen expression by EC (HLA-DR+KC) were studied. Furthermore, the immunologic role of HLA-DR+KC in the mixed epidermal cell-lymphocyte reaction (MECLR) was studied. The antiproliferative effect of gamma-IFN on the cultured EC was seen 3 days after treatment of gamma-IFN and the effect was dose-dependent. Number of HLA-DR+KC was increased dose-dependently with treatment of gamma-IFN. In MECLR, HLA-DR+KC had been found to exert stimulatory role on allogenic lymphocytes. However, there was no significant role of HLA-DR+KC on autologous lymphocytes.

Keyword

Epidermal cell (EC); Gamma-interferon (gamma-IFN) HLA-DR positive kerationocyte (HLA-DR+KC); Langerhans cell (LC); Mixed epidermal cell-lymphocyte reaction (MECLR); Peripheral blood lymphocytes (PBL)

MeSH Terms

Adolescent
Adult
Cell Division/*drug effects
Female
HLA-DR Antigens/*immunology
Humans
Interferon-gamma/*pharmacology
Lymphocytes/cytology/drug effects/*immunology
Male
Skin/*cytology/drug effects
HLA-DR Antigens
Interferon-gamma