Korean J Radiol.  2012 Oct;13(5):625-633. 10.3348/kjr.2012.13.5.625.

Radiofrequency Ablation of Renal Tumors: Four-Year Follow-Up Results in 47 Patients

  • 1Department of Urology, Dong-A University College of Medicine, Busan 602-714, Korea. sunggt@dau.ac.kr
  • 2Department of Radiology, Dong-A University College of Medicine, Busan 602-714, Korea.


To retrospectively evaluate the intermediate results of radiofrequency ablation (RFA) of small renal masses (SRMs).
Percutaneous or laparoscopic RFA was performed on 48 renal tumors in 47 patients. The follow-up studies included a physical examination, chest radiography, creatinine level, and contrast-enhanced CT or MRI. To confirm the pathologic criteria of complete ablation, 35 patients underwent a follow-up biopsy. Recurrence was defined as contrast enhancement on imaging studies after 3 months, lesion growth at subsequent imaging, or viable cancer cells on follow-up biopsy.
Technical success was achieved in 43 (89.6%) of 48 renal tumors. The mean tumor size was 2.3 cm and the mean follow-up period was 49.6 months. Repeated RFA was necessary in 5 tumors due to incomplete ablation. The overall complication rate was 35.8%, of which 96.2% were mild complications. Serum creatinine levels at 12 months after RFA did not differ from those before RFA (1.28 vs. 1.36 mg/dL). Four patients were found to have recurrence at various follow-up intervals, and distant metastasis was not found in any cases.
RFA appears to be a useful treatment for selected patients with SRMs. Our 4-year follow-up results disclose an excellent therapeutic outcome with RFA, while achieving effective local tumor control.


Radiofrequency ablation; Kidney tumors; Minimally invasive surgical procedures

MeSH Terms

Catheter Ablation/*methods
Contrast Media/diagnostic use
Follow-Up Studies
Kidney Neoplasms/*surgery
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local
Postoperative Complications
Radiography, Thoracic
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome


  • Fig. 1 Well ablated, small intraparenchymal renal cell carcinoma in 62-year-old male who underwent radiofrequency ablation (RFA). A. Contrast-enhanced CT scan before RFA demonstrates 2.1 cm solid enhancing renal tumor located at upper pole posterior region of right kidney. B. One month follow-up contrast-enhanced CT scan demonstrates absence of periablation enhancement or residual contrast enhancement within tumor bed indicating technical success.

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Jonas Scheck, Philipp Bruners, David Schindler, Christiane Kuhl, Peter Isfort
Korean J Radiol. 2018;19(4):560-567.    doi: 10.3348/kjr.2018.19.4.560.


1. Bosniak MA, Birnbaum BA, Krinsky GA, Waisman J. Small renal parenchymal neoplasms: further observations on growth. Radiology. 1995. 197:589–597.
2. Lucas SM, Stern JM, Adibi M, Zeltser IS, Cadeddu JA, Raj GV. Renal function outcomes in patients treated for renal masses smaller than 4 cm by ablative and extirpative techniques. J Urol. 2008. 179:75–79. discussion 79-80.
3. Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006. 7:735–740.
4. Campbell SC, Novick AC, Belldegrun A, Blute ML, Chow GK, Derweesh IH, et al. Guideline for management of the clinical T1 renal mass. J Urol. 2009. 182:1271–1279.
5. Herr HW. Partial nephrectomy for unilateral renal carcinoma and a normal contralateral kidney: 10-year followup. J Urol. 1999. 161:33–34. discussion 34-35.
6. Fergany AF, Hafez KS, Novick AC. Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol. 2000. 163:442–445.
7. Gill IS, Kavoussi LR, Lane BR, Blute ML, Babineau D, Colombo JR Jr, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007. 178:41–46.
8. Park H, Byun SS, Kim HH, Lee SB, Kwon TG, Jeon SH, et al. Comparison of laparoscopic and open partial nephrectomies in t1a renal cell carcinoma: a Korean multicenter experience. Korean J Urol. 2010. 51:467–471.
9. Pasticier G, Timsit MO, Badet L, De La Torre Abril L, Halila M, Fassi Fehri H, et al. Nephron-sparing surgery for renal cell carcinoma: detailed analysis of complications over a 15-year period. Eur Urol. 2006. 49:485–490.
10. Zlotta AR, Wildschutz T, Raviv G, Peny MO, van Gansbeke D, Noel JC, et al. Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: ex vivo and in vivo experience. J Endourol. 1997. 11:251–258.
11. Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR. Radiofrequency ablation of renal cell carcinoma: part 1, Indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol. 2005. 185:64–71.
12. Matsumoto ED, Johnson DB, Ogan K, Trimmer C, Sagalowsky A, Margulis V, et al. Short-term efficacy of temperature-based radiofrequency ablation of small renal tumors. Urology. 2005. 65:877–881.
13. Park SH, Yoon SK, Cho JH, Oh JY, Nam KJ, Kwon HJ, et al. Radiofrequency ablation treatment for renal cell carcinoma: early clinical experience. Korean J Radiol. 2008. 9:340–347.
14. Farrell MA, Charboneau WJ, DiMarco DS, Chow GK, Zincke H, Callstrom MR, et al. Imaging-guided radiofrequency ablation of solid renal tumors. AJR Am J Roentgenol. 2003. 180:1509–1513.
15. Park S, Anderson JK, Matsumoto ED, Lotan Y, Josephs S, Cadeddu JA. Radiofrequency ablation of renal tumors: intermediate-term results. J Endourol. 2006. 20:569–573.
16. Kim JH, Kim TH, Kim SD, Lee KS, Sung GT. Radiofrequency ablation of renal tumors: our experience. Korean J Urol. 2011. 52:531–537.
17. Wingo MS, Leveillee RJ. Central and deep renal tumors can be effectively ablated: radiofrequency ablation outcomes with fiberoptic peripheral temperature monitoring. J Endourol. 2008. 22:1261–1267.
18. Mylona S, Kokkinaki A, Pomoni M, Galani P, Ntai S, Thanos L. Percutaneous radiofrequency ablation of renal cell carcinomas in patients with solitary kidney: 6 years experience. Eur J Radiol. 2009. 69:351–356.
19. Watkins TW, Parkinson R. Percutaneous radiofrequency ablation of renal tumours: case series of 11 tumours and review of published work. Australas Radiol. 2007. 51:412–419.
20. Salas N, Ramanathan R, Dummett S, Leveillee RJ. Results of radiofrequency kidney tumor ablation: renal function preservation and oncologic efficacy. World J Urol. 2010. 28:583–591.
21. Breen DJ, Rutherford EE, Stedman B, Roy-Choudhury SH, Cast JE, Hayes MC, et al. Management of renal tumors by image-guided radiofrequency ablation: experience in 105 tumors. Cardiovasc Intervent Radiol. 2007. 30:936–942.
22. Arima K, Yamakado K, Kinbara H, Nakatsuka A, Takeda K, Sugimura Y. Percutaneous radiofrequency ablation with transarterial embolization is useful for treatment of stage 1 renal cell carcinoma with surgical risk: results at 2-year mean follow up. Int J Urol. 2007. 14:585–590. discussion 590.
23. Zagoria RJ, Traver MA, Werle DM, Perini M, Hayasaka S, Clark PE. Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinomas. AJR Am J Roentgenol. 2007. 189:429–436.
24. Weight CJ, Kaouk JH, Hegarty NJ, Remer EM, O'Malley CM, Lane BR, et al. Correlation of radiographic imaging and histopathology following cryoablation and radio frequency ablation for renal tumors. J Urol. 2008. 179:1277–1281. discussion 1281-1283.
25. Tracy CR, Raman JD, Donnally C, Trimmer CK, Cadeddu JA. Durable oncologic outcomes after radiofrequency ablation: experience from treating 243 small renal masses over 7.5 years. Cancer. 2010. 116:3135–3142.
26. Raman JD, Stern JM, Zeltser I, Kabbani W, Cadeddu JA. Absence of viable renal carcinoma in biopsies performed more than 1 year following radio frequency ablation confirms reliability of axial imaging. J Urol. 2008. 179:2142–2145.
27. Aron M, Gill IS. Renal tumor ablation. Curr Opin Urol. 2005. 15:298–305.
28. Kwan KG, Matsumoto ED. Radiofrequency ablation and cryoablation of renal tumours. Curr Oncol. 2007. 14:34–38.
29. Arzola J, Baughman SM, Hernandez J, Bishoff JT. Computed tomography-guided, resistance-based, percutaneous radiofrequency ablation of renal malignancies under conscious sedation at two years of follow-up. Urology. 2006. 68:983–987.
30. Levinson AW, Su LM, Agarwal D, Sroka M, Jarrett TW, Kavoussi LR, et al. Long-term oncological and overall outcomes of percutaneous radio frequency ablation in high risk surgical patients with a solitary small renal mass. J Urol. 2008. 180:499–504. discussion 504.
31. Ahrar K, Matin S, Wood CG, Wallace MJ, Gupta S, Madoff DC, et al. Percutaneous radiofrequency ablation of renal tumors: technique, complications, and outcomes. J Vasc Interv Radiol. 2005. 16:679–688.
32. Mahnken AH, Rohde D, Brkovic D, Günther RW, Tacke JA. Percutaneous radiofrequency ablation of renal cell carcinoma: preliminary results. Acta Radiol. 2005. 46:208–214.
33. Kümmerlin IP, Borrego J, Wink MH, Van Dijk MM, Wijkstra H, de la Rosette JJ, et al. Nephron-sparing surgery and percutaneous biopsies in renal-cell carcinoma: a global impression among endourologists. J Endourol. 2007. 21:709–713.
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