Korean J Radiol.  2012 Oct;13(5):625-633. 10.3348/kjr.2012.13.5.625.

Radiofrequency Ablation of Renal Tumors: Four-Year Follow-Up Results in 47 Patients

Affiliations
  • 1Department of Urology, Dong-A University College of Medicine, Busan 602-714, Korea. sunggt@dau.ac.kr
  • 2Department of Radiology, Dong-A University College of Medicine, Busan 602-714, Korea.

Abstract


OBJECTIVE
To retrospectively evaluate the intermediate results of radiofrequency ablation (RFA) of small renal masses (SRMs).
MATERIALS AND METHODS
Percutaneous or laparoscopic RFA was performed on 48 renal tumors in 47 patients. The follow-up studies included a physical examination, chest radiography, creatinine level, and contrast-enhanced CT or MRI. To confirm the pathologic criteria of complete ablation, 35 patients underwent a follow-up biopsy. Recurrence was defined as contrast enhancement on imaging studies after 3 months, lesion growth at subsequent imaging, or viable cancer cells on follow-up biopsy.
RESULTS
Technical success was achieved in 43 (89.6%) of 48 renal tumors. The mean tumor size was 2.3 cm and the mean follow-up period was 49.6 months. Repeated RFA was necessary in 5 tumors due to incomplete ablation. The overall complication rate was 35.8%, of which 96.2% were mild complications. Serum creatinine levels at 12 months after RFA did not differ from those before RFA (1.28 vs. 1.36 mg/dL). Four patients were found to have recurrence at various follow-up intervals, and distant metastasis was not found in any cases.
CONCLUSION
RFA appears to be a useful treatment for selected patients with SRMs. Our 4-year follow-up results disclose an excellent therapeutic outcome with RFA, while achieving effective local tumor control.

Keyword

Radiofrequency ablation; Kidney tumors; Minimally invasive surgical procedures

MeSH Terms

Adult
Aged
Catheter Ablation/*methods
Contrast Media/diagnostic use
Female
Follow-Up Studies
Humans
Kidney Neoplasms/*surgery
Laparoscopy
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Recurrence, Local
Postoperative Complications
Radiography, Thoracic
Reoperation
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome

Figure

  • Fig. 1 Well ablated, small intraparenchymal renal cell carcinoma in 62-year-old male who underwent radiofrequency ablation (RFA). A. Contrast-enhanced CT scan before RFA demonstrates 2.1 cm solid enhancing renal tumor located at upper pole posterior region of right kidney. B. One month follow-up contrast-enhanced CT scan demonstrates absence of periablation enhancement or residual contrast enhancement within tumor bed indicating technical success.


Cited by  1 articles

Comparison of Chronologic Change in the Size and Contrast-Enhancement of Ablation Zones on CT Images after Irreversible Electroporation and Radiofrequency Ablation
Jonas Scheck, Philipp Bruners, David Schindler, Christiane Kuhl, Peter Isfort
Korean J Radiol. 2018;19(4):560-567.    doi: 10.3348/kjr.2018.19.4.560.


Reference

1. Bosniak MA, Birnbaum BA, Krinsky GA, Waisman J. Small renal parenchymal neoplasms: further observations on growth. Radiology. 1995. 197:589–597.
2. Lucas SM, Stern JM, Adibi M, Zeltser IS, Cadeddu JA, Raj GV. Renal function outcomes in patients treated for renal masses smaller than 4 cm by ablative and extirpative techniques. J Urol. 2008. 179:75–79. discussion 79-80.
3. Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006. 7:735–740.
4. Campbell SC, Novick AC, Belldegrun A, Blute ML, Chow GK, Derweesh IH, et al. Guideline for management of the clinical T1 renal mass. J Urol. 2009. 182:1271–1279.
5. Herr HW. Partial nephrectomy for unilateral renal carcinoma and a normal contralateral kidney: 10-year followup. J Urol. 1999. 161:33–34. discussion 34-35.
6. Fergany AF, Hafez KS, Novick AC. Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol. 2000. 163:442–445.
7. Gill IS, Kavoussi LR, Lane BR, Blute ML, Babineau D, Colombo JR Jr, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007. 178:41–46.
8. Park H, Byun SS, Kim HH, Lee SB, Kwon TG, Jeon SH, et al. Comparison of laparoscopic and open partial nephrectomies in t1a renal cell carcinoma: a Korean multicenter experience. Korean J Urol. 2010. 51:467–471.
9. Pasticier G, Timsit MO, Badet L, De La Torre Abril L, Halila M, Fassi Fehri H, et al. Nephron-sparing surgery for renal cell carcinoma: detailed analysis of complications over a 15-year period. Eur Urol. 2006. 49:485–490.
10. Zlotta AR, Wildschutz T, Raviv G, Peny MO, van Gansbeke D, Noel JC, et al. Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: ex vivo and in vivo experience. J Endourol. 1997. 11:251–258.
11. Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR. Radiofrequency ablation of renal cell carcinoma: part 1, Indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol. 2005. 185:64–71.
12. Matsumoto ED, Johnson DB, Ogan K, Trimmer C, Sagalowsky A, Margulis V, et al. Short-term efficacy of temperature-based radiofrequency ablation of small renal tumors. Urology. 2005. 65:877–881.
13. Park SH, Yoon SK, Cho JH, Oh JY, Nam KJ, Kwon HJ, et al. Radiofrequency ablation treatment for renal cell carcinoma: early clinical experience. Korean J Radiol. 2008. 9:340–347.
14. Farrell MA, Charboneau WJ, DiMarco DS, Chow GK, Zincke H, Callstrom MR, et al. Imaging-guided radiofrequency ablation of solid renal tumors. AJR Am J Roentgenol. 2003. 180:1509–1513.
15. Park S, Anderson JK, Matsumoto ED, Lotan Y, Josephs S, Cadeddu JA. Radiofrequency ablation of renal tumors: intermediate-term results. J Endourol. 2006. 20:569–573.
16. Kim JH, Kim TH, Kim SD, Lee KS, Sung GT. Radiofrequency ablation of renal tumors: our experience. Korean J Urol. 2011. 52:531–537.
17. Wingo MS, Leveillee RJ. Central and deep renal tumors can be effectively ablated: radiofrequency ablation outcomes with fiberoptic peripheral temperature monitoring. J Endourol. 2008. 22:1261–1267.
18. Mylona S, Kokkinaki A, Pomoni M, Galani P, Ntai S, Thanos L. Percutaneous radiofrequency ablation of renal cell carcinomas in patients with solitary kidney: 6 years experience. Eur J Radiol. 2009. 69:351–356.
19. Watkins TW, Parkinson R. Percutaneous radiofrequency ablation of renal tumours: case series of 11 tumours and review of published work. Australas Radiol. 2007. 51:412–419.
20. Salas N, Ramanathan R, Dummett S, Leveillee RJ. Results of radiofrequency kidney tumor ablation: renal function preservation and oncologic efficacy. World J Urol. 2010. 28:583–591.
21. Breen DJ, Rutherford EE, Stedman B, Roy-Choudhury SH, Cast JE, Hayes MC, et al. Management of renal tumors by image-guided radiofrequency ablation: experience in 105 tumors. Cardiovasc Intervent Radiol. 2007. 30:936–942.
22. Arima K, Yamakado K, Kinbara H, Nakatsuka A, Takeda K, Sugimura Y. Percutaneous radiofrequency ablation with transarterial embolization is useful for treatment of stage 1 renal cell carcinoma with surgical risk: results at 2-year mean follow up. Int J Urol. 2007. 14:585–590. discussion 590.
23. Zagoria RJ, Traver MA, Werle DM, Perini M, Hayasaka S, Clark PE. Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinomas. AJR Am J Roentgenol. 2007. 189:429–436.
24. Weight CJ, Kaouk JH, Hegarty NJ, Remer EM, O'Malley CM, Lane BR, et al. Correlation of radiographic imaging and histopathology following cryoablation and radio frequency ablation for renal tumors. J Urol. 2008. 179:1277–1281. discussion 1281-1283.
25. Tracy CR, Raman JD, Donnally C, Trimmer CK, Cadeddu JA. Durable oncologic outcomes after radiofrequency ablation: experience from treating 243 small renal masses over 7.5 years. Cancer. 2010. 116:3135–3142.
26. Raman JD, Stern JM, Zeltser I, Kabbani W, Cadeddu JA. Absence of viable renal carcinoma in biopsies performed more than 1 year following radio frequency ablation confirms reliability of axial imaging. J Urol. 2008. 179:2142–2145.
27. Aron M, Gill IS. Renal tumor ablation. Curr Opin Urol. 2005. 15:298–305.
28. Kwan KG, Matsumoto ED. Radiofrequency ablation and cryoablation of renal tumours. Curr Oncol. 2007. 14:34–38.
29. Arzola J, Baughman SM, Hernandez J, Bishoff JT. Computed tomography-guided, resistance-based, percutaneous radiofrequency ablation of renal malignancies under conscious sedation at two years of follow-up. Urology. 2006. 68:983–987.
30. Levinson AW, Su LM, Agarwal D, Sroka M, Jarrett TW, Kavoussi LR, et al. Long-term oncological and overall outcomes of percutaneous radio frequency ablation in high risk surgical patients with a solitary small renal mass. J Urol. 2008. 180:499–504. discussion 504.
31. Ahrar K, Matin S, Wood CG, Wallace MJ, Gupta S, Madoff DC, et al. Percutaneous radiofrequency ablation of renal tumors: technique, complications, and outcomes. J Vasc Interv Radiol. 2005. 16:679–688.
32. Mahnken AH, Rohde D, Brkovic D, Günther RW, Tacke JA. Percutaneous radiofrequency ablation of renal cell carcinoma: preliminary results. Acta Radiol. 2005. 46:208–214.
33. Kümmerlin IP, Borrego J, Wink MH, Van Dijk MM, Wijkstra H, de la Rosette JJ, et al. Nephron-sparing surgery and percutaneous biopsies in renal-cell carcinoma: a global impression among endourologists. J Endourol. 2007. 21:709–713.
Full Text Links
  • KJR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr