Clin Mol Hepatol.  2012 Sep;18(3):258-267. 10.3350/cmh.2012.18.3.258.

Changes of guidelines diagnosing hepatocellular carcinoma during the last ten-year period

  • 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.


Hepatocellular carcinoma (HCC) is the third most common cause of cancer deaths in the world. There have been many advances in the diagnosis of HCC during the last ten years, especially in the imaging techniques. The Korean Liver cancer study group (KLCSG), European Association for the Study of the Liver (EASL), American Association for the Study of Liver disease (AASLD), and Asian-Pacific Association for the Study of Liver (APASL) have made and changed the HCC guidelines with the advances in the imaging techniques and according to the results of the researches on HCC. We reviewed the changes of the imaging guidelines in HCC diagnosis according to the advances in the imaging techniques. Further studies will be necessary to resolve the controversies in the diagnosis of HCC smaller than 1 cm in size.


Hepatocellular carcinoma; Diagnosis; Guideline

MeSH Terms

Carcinoma, Hepatocellular/complications/*diagnosis/pathology
Hepatitis B/complications
Hepatitis C/complications
Liver Cirrhosis/complications
Liver Neoplasms/complications/*diagnosis/pathology
Magnetic Resonance Imaging
*Practice Guidelines as Topic
Risk Factors
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