Korean J Parasitol.
2012 Sep;50(3):229-231. 10.3347/kjp.2012.50.3.229.
Detection of Ocular Toxoplasma gondii Infection in Chronic Irregular Recurrent Uveitis by PCR
- Affiliations
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- 1Division of Malaria and Parasitic Diseases, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong 363-951, Korea. wonja@nih.go.kr
- 2R & D Center, Lumieye Genetics Co. Ltd., Seoul 135-280, Korea.
- 3The Retina Center, Nune Eye Hospital, Seoul 135-280, Korea.
- KMID: 1387410
- DOI: http://doi.org/10.3347/kjp.2012.50.3.229
Abstract
- Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.
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