Korean J Hepatol.  2009 Dec;15(4):454-463. 10.3350/kjhep.2009.15.4.454.

Comparison of various noninvasive serum markers of liver fibrosis in chronic viral liver disease

• Kim SM
• Sohn JH
• Kim TY
• Roh YW
• Eun CS
• Jeon YC
• Han DS
• Oh YH

• KMID: 1384053
• DOI: http://doi.org/10.3350/kjhep.2009.15.4.454

Abstract

BACKGROUND/AIMS
The aim of this study was to determine the clinical performances of noninvasive serum markers for the prediction of liver fibrosis in chronic viral liver diseases. METHODS: We analyzed a total of 225 patients with chronic viral liver diseases (180 with hepatitis B virus, 43 with hepatitis C virus, and 2 with hepatitis B+C virus) who underwent a liver biopsy procedure at the Hanyang University Guri Hospital between March 2002 and February 2007. Serum was also obtained at the time of liver biopsy. Liver fibrosis was staged according to the scoring system proposed by the Korean Study Group for the Pathology of Digestive Diseases. Various noninvasive serum markers were evaluated, including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), age-platelet (AP) index, AST/platelet ratio index (APRI), cirrhosis discriminant score (CDS), platelet count, hyaluronic acid (HA), and type IV collagen. RESULTS: There were 17, 40, 61, 74, and 33 patients at stages F0, F1, F2, F3, and F4, respectively. The overall diagnostic accuracies of each marker, as determined by the area under receiver operating characteristics curves, were APRI=0.822, CDS=0.776, platelet count=0.773, AP index=0.756, HA=0.749, type IV collagen=0.718, and AAR=0.642 for predicting significant fibrosis (> or =F2); and CDS=0.835, platelet count=0.795, AP index=0.794, HA=0.766, AAR=0.711, type IV collagen=0.697, and APRI=0.691 for predicting extensive fibrosis (> or =F3). CONCLUSIONS: All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis.

Keyword

Chronic viral liver disease; Liver fibrosis; Noninvasive serum markers

MeSH Terms

Adult
Alanine Transaminase/blood
Area Under Curve
Aspartate Aminotransferases/blood
Biological Markers/blood
Collagen Type IV
Female
Hepatitis B, Chronic/*complications
Hepatitis C, Chronic/*complications
Humans
Hyaluronic Acid/blood
Liver Cirrhosis/*diagnosis/virology
Male
Middle Aged
Platelet Count
Predictive Value of Tests
Severity of Illness Index