Ann Lab Med.  2012 Jul;32(4):298-303. 10.3343/alm.2012.32.4.298.

Lung Infection Caused by Mycobacterium riyadhense Confused with Mycobacterium tuberculosis: The First Case in Korea

  • 1Department of Laboratory Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 2Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.


A slowly growing, non-chromogenic mycobacterial strain was isolated from sputum and bronchial lavage fluid samples of a patient presenting with productive cough, blood-tinged sputum, low-grade fever, and weakness. A positive acid-fast bacilli sputum smear result prompted the initiation of an anti-tuberculosis regimen. Multiplex real-time PCR showed a negative result for Mycobacterium tuberculosis complex and a positive result for nontuberculous mycobacteria. The DNA chip test confirmed this organism as a member of the genus Mycobacterium, but could not specify the species. Interestingly, the mycolic acid patterns obtained by HPLC nearly overlapped with those of M. simulans. The sequences of the Mycobacterium 16S rRNA gene and 16S-23S internal transcribed spacer region were unique and were found to have 100% similarity with those of M. riyadhense. After a review of the literature, we report this case as the first Korean case of M. riyadhense lung infection.


Nontuberculous mycobacteria; Mycobacterium; Mycobacterium riyadhense; Mycobacterium simulans

MeSH Terms

Antitubercular Agents/pharmacology
Chromatography, High Pressure Liquid
Lung Diseases/*microbiology
Microbial Sensitivity Tests
Mycobacterium/classification/drug effects/*isolation & purification
Mycobacterium Infections/microbiology
Mycobacterium tuberculosis/genetics/isolation & purification
Mycolic Acids/analysis
Oligonucleotide Array Sequence Analysis
RNA, Ribosomal, 16S/chemistry/genetics
RNA, Ribosomal, 23S/chemistry/genetics
Republic of Korea
Sequence Analysis, DNA
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