J Vet Sci.  2011 Dec;12(4):409-411. 10.4142/jvs.2011.12.4.409.

Atypical necrotizing encephalitis associated with systemic canine distemper virus infection in pups

Affiliations
  • 1Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, P.O. Box 6001, 86051-990, Parana, Brazil. headleysa@gmail.com
  • 2Department of Small Animal Clinical Science, Faculty of Veterinary Medicine, Universidade de Cuiaba, Cuiaba, Mato Grosso, 78.065-420, Brazil.
  • 3Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Fin-0014, Finland.
  • 4School of Veterinary Medicine, St. Matthew's University, Georgetown, Grand Cayman, KY1-1209, Cayman Islands, British West Indies.
  • 5Department of Veterinary Clinics, Universidade Estadual de Londrina, P.O. Box 6001, 86051-990, Parana, Brazil.

Abstract

This report describes the naturally occurring atypical neuropathological manifestation of systemic canine distemper virus (CDV) infection in two 16-day-old Pit Bull pups. CDV-induced changes affected the gray and white matter of the forebrain while sparing the hindbrain. Histologically, there was necrosis with destruction of the nervous parenchyma due to an influx of inflammatory and reactive cells associated with eosinophilic intranuclear inclusion bodies within glial cells. Positive immunoreactivity against CDV antigens was predominantly observed within astrocytes and neurons. RT-PCR was used to amplify CDV-specific amplicons from brain fragments. These findings suggest the participation of CDV in the etiopathogenesis of these lesions.

Keyword

canine distemper virus; immunohistochemistry; neuropathology; RT-PCR

MeSH Terms

Animals
Antigens, Viral
Central Nervous System/pathology/virology
Distemper/*virology
*Distemper Virus, Canine
Dogs
Encephalitis/pathology/*veterinary/virology
Necrosis/pathology/*veterinary/virology
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