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Mapping of folic acid in the children brainstem

Duque-Díaz E, Coveñas R

Using highly specific antisera, the neuroanatomical distribution of folic acid (FA) and retinoic acid (RA) has been studied for the first time in the children brainstem. Neither immunoreactive structures containing...
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Clinical, histological, and deep learning-based assessments and treatment of oral verruciform xanthoma: a case report

Lee JH, Jeong SN

Verruciform xanthoma is a benign growth found on the oral mucosa. Clinically, verruciform xanthoma is an asymptomatic lesion, and depending on the amount of keratin present on the surface of...
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Sarcomatoid Squamous Cell Carcinoma of the Lower Lip: A Case Report

Nam KH, Lee IJ, Lee SK, Park J, Kim HU, Yun SK

  • KMID: 2520803
  • Korean J Dermatol.
  • 2021 Sep;59(8):640-643.
Sarcomatoid squamous cell carcinoma (SSCC) is a rare malignancy with distinct carcinomatous and sarcomatous features. SSCCs involving the lung, esophagus bladder, and skin have been reported as rare case reports....
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Atypical Fibroxanthoma of the Thigh in a 12-Year-Old Adolescent: A Case Report

Kim JH, Uh JA, Lee JH, Lee SK, Kim MS, Lee UH

  • KMID: 2519517
  • Korean J Dermatol.
  • 2021 Aug;59(7):550-554.
Atypical fibroxanthoma (AFX) is a rare fibrohistiocytic tumor usually observed on ultraviolet light-exposed areas of the body, such as the face or scalp in elderly individuals. Despite its clinically benign...
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Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon HM, Kim GY, Shin DH, Bae YK

Background: Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological...
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Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type

Rustamadji P, Wiyarta E, Bethania KA, Kusmardi K

Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2...
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Distinctive morphological and molecular features of urothelial carcinoma with an inverted growth pattern

Sanguedolce F, Calò B, Chirico M, Falagario U, Busetto GM, Zanelli M, Bisagni A, Zizzo M, Ascani S, Carrieri G, Cormio L

Urothelial carcinoma with an inverted growth pattern (UC-IGP) is a peculiar entity within the spectrum of urothelial lesions. While efforts have been made over the last few decades to unravel...
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COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical, and Ultrastructural Study of the Human Penis

Kresch E, Achua J, Saltzman R, Khodamoradi K, Arora H, Ibrahim E, Kryvenko ON, Almeida VW, Firdaus F, Hare JM, Ramasamy R

Purpose: A pilot study to describe histopathological features of penile tissue of patients who recovered from symptomatic COVID-19 infection and subsequently developed severe erectile dysfunction (ED). Materials and Methods: Penile tissue...
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Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model

Park SY, Choi SR, Kim JH, Lee SC, Jeong SY, Jeong JH, Lee TY

Objectives: Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on...
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Characteristics of HER2-Positive Breast Cancer according to HER2 2+/ Low or 3+/High Classification by Immunohistochemistry Assay: Study of 205 Cases Treated in a Single Center

Lee C, Park I, Kim J, Cho H, Yang K, Lee Y, Park K, Kim J, Shin Y, Gwak G

Purpose: To investigate the characteristics of HER2-positive breast cancer according to HER2 low (2+) or high (3+) classification using immunohistochemistry (IHC). Methods: Data were collected from 205 HER2-positive breast cancer...
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Programmed Death Ligand 1 Immunohistochemistry in TripleNegative Breast Cancer: Evaluation of Inter-Pathologist Concordance and Inter-Assay Variability

Purpose: The programmed death ligand 1 (PD-L1) SP142 assay with a 1% immune cell (IC) cutoff is approved for the selection of advanced triple-negative breast cancer (TNBC) patients for atezolizumab...
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Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease

Tsutsumi N, Nishimata S, Shimura M, Kashiwagi Y, Kawashima H

Purpose: Hepcidin levels have previously been reported to be correlated with liver damage.However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This...
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Pathologically and Genetically Diagnosed Subclinical Symptomatic Duchenne Muscular Dystrophy Carrier: Broadened Spectrum of Clinical Phenotype

Cho MS, Lee JM

A 29-year-old female presented with an elevated level of serum creatine kinase without subjective weakness. Neurologic examination showed the subtle motor weakness of the right arm. Muscle biopsy showed dystrophic...
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Association of immunohistochemical markers of tumor subtype with response to neoadjuvant chemotherapy and survival in patients with muscle-invasive bladder cancer

Razzaghdoust A, Ghajari M, Basiri A, Torbati PM, Jafari A, Fattahi MR, Salahi M, Mofid B

Purpose: A readily accessible biomarker to identify which patients with bladder cancer are more likely to respond to neoadjuvant chemotherapy (NAC) could help clinicians avoid unnecessary chemotherapy and prevent its...
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Prognostic Significance of the Expression of Claudin-1 in Head and Neck Squamous Cell Carcinoma

Lee J, Kim SW, Lee SH, Jin SM, Do SI, Lee HJ

Background and Objectives Claudin-1 (CLDN-1) is the major component of tight junctions and functions in controlling cell to cell adhesion. Certain claudins were expressed aberrantly and proved to have prognostic...
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Nicotine impact on rat substantia nigra compacta

Elgayar SAM, Hussein OA, Mubarak HA, Ismaiel AM, Gomaa AM

Nicotine neuronal interactions exert an adverse potential in some brain regions and a significant link has been established between tobacco smoke/nicotine and vascular impairment. This work addresses nicotine impact on...
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Optimal panel of immunohistochemistry for the diagnosis of B-cell non-Hodgkin lymphoma using bone marrow biopsy: a tertiary care center study

Marwah N, Satiza M, Dalal N, Atri S, Gupta M, Singh S, Sen R

Background: Morphological diagnosis of non-Hodgkin lymphoma (NHL) is usually based on lymph node biopsy. Bone marrow biopsy (BMB) is important for staging, and morphology alone can be challenging for subtyping....
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The prognostic significance of p16 expression pattern in diffuse gliomas

Park JW, Kang J, Lim KY, Kim H, Kim SI, Won JK, Park CK, Park SH

Background: CDKN2A is a tumor suppressor gene that encodes the cell cycle inhibitor protein p16. Homozygous deletion of the CDKN2A gene has been associated with shortened survival in isocitrate dehydrogenase...
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Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer

Min SK, Lee SK, Woo J, Jung SM, Ryu JM, Yu J, Lee JE, Kim SW, Chae BJ, Nam SJ

Purpose: Tumor size and lymph node metastasis are important factors that contribute to the progression of breast cancer. We aimed to analyze the relationship between tumor size and lymph node...
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DNA-protein biomarkers for immunotherapy in the era of precision oncology

Kim B, Kang SY, Kim KM

The use of biomarkers to guide patient and therapy selection has gained much attention to increase the scope and complexity of targeted therapy options and immunotherapy. Clinical trials provide a...
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