J Korean Rheum Assoc.  2008 Mar;15(1):58-62. 10.4078/jkra.2008.15.1.58.

Kikuchi-Fujimoto's Disease with Adult Onset Still's Disease

• Kang EJ
• Choi ST
• Lee SW
• Jung SY
• Son MK
• Lee KH
• Yang WI
• Park YB
• Lee SK

• KMID: 1324510
• DOI: http://doi.org/10.4078/jkra.2008.15.1.58

Abstract

Kikuchi-Fujimoto's disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign and self-limiting disease. KFD are confused with systemic autoimmune disease as they present with localized lymphadenopathy, fever, fatigue, arthritis, leukopenia. Furthermore as KFD can occur associated with other autoimmune disease, we need to diagnose carefully. Here, we describe a case of 27-year-old female patient, diagnosed as KFD, who subsequently developed adult onset Still's disesase (AOSD). As far as we know, this is the first case of KFD with AOSD in Korea.

Keyword

Kikuchi-Fujimoto's disease; AOSD; Lymphadenopathy

MeSH Terms

Adult
Male
Female
Humans

Figure

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  Fig. 1. Neck computed tomography scan shows mild hyperplasia of lingular tonsils (arrow head) and multiple lymphadenopathies (arrow) bilaterally.

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  Fig. 2. Lymph node biopsy shows necrotizing lesion composed of various histiocytes, plasmacytoid monocytes and lymphoid cells with karyorrhectic nuclear debris (H&E, original magnification ×200).

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  Fig. 3. Changes of liver function tests and serum ferritin level during the course of treatment. LDH: lactate dehydrogenase, AST: aspartate aminotransferase, ALT: alanine aminotransferase.

Reference

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