J Korean Med Sci.
2002 Oct;17(5):704-707. 10.3346/jkms.2002.17.5.704.
Plasma Cell Granuloma in Cyclosporine-Induced Gingival Overgrowth: A Report of Two Cases with Immunohistochemical Positivity of Interleukin-6 and Phospholipase C-gamma1
- Affiliations
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- 1Department of Pathology, Medical School, University of Ulsan, Ulsan, Korea. sungmin@mm.ewha.ac.kr
- 2Department of Oral Surgery, Medical School, University of Ulsan, Ulsan, Korea.
- 3Immune Cell Signal Transduction RU, Korea.
- 4Research Institute of Bioscience and Biotechnology, Daejon, Korea.
- 5Department of Life Science, Pohang University of Science and Technology, Pohang, Korea.
- 6Department of Otolaryngology, Ewha Womans University Hospital, Seoul, Korea.
- KMID: 1127268
- DOI: http://doi.org/10.3346/jkms.2002.17.5.704
Abstract
- We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C-gamma1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
MeSH Terms
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Cyclosporine/adverse effects
Female
Gingival Diseases/*chemically induced/enzymology/immunology/pathology
Granuloma, Plasma Cell/*chemically induced/enzymology/immunology/pathology
Humans
Immunohistochemistry
Immunosuppressive Agents/adverse effects
Interleukin-6/metabolism
Kidney Transplantation
Male
Middle Aged
Phospholipase C gamma
Type C Phospholipases/metabolism
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