- PLC-gamma1 for Differentiating Adenocarcinoma from Reactive Mesothelial Cells in Effusions
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Ju WY, Kim SS
- KMID: 1545413
- Korean J Cytopathol.
- 1997 Dec;8(2):115-119.
Cytologic diagnosis of reactive or malignant effusion is sometimes difficult. Espe- cially, differentiation of benign reactive mesothelial cells from malignant cells in body effusion is more difficult. Recently, immunohistochemistry has... -
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- The Pattern of Expression of Phospholipase C-gamma in Benign and Malignant Tumors of the Breast
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Kim HJ, Chung KW, Kim SW, Moon BI, Ahn SJ, Noh DY, Yoo KY, Choe KJ
- KMID: 2209462
- J Korean Surg Soc.
- 2002 Jun;62(6):463-467.
PURPOSE: The activation of phospholipase C (PLC) is one of the early events in various growth processes, including malignant transformation. Among PLC-isozymes, PLC-gamma is activated through direct interaction with growth... -
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- Plasma Cell Granuloma in Cyclosporine-Induced Gingival Overgrowth: A Report of Two Cases with Immunohistochemical Positivity of Interleukin-6 and Phospholipase C-gamma1
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Kim SS, Eom DW, Huh JR, Sung IY, Choi IP, Ryu SH, Suh PG, Chung SM
- KMID: 1127268
- J Korean Med Sci.
- 2002 Oct;17(5):704-707.
- doi: 10.3346/jkms.2002.17.5.704
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions... -
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- Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain
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Kim SK, Choi JH, Suh PG, Chang JS
- KMID: 1094152
- Exp Mol Med.
- 2006 Jun;38(3):265-272.
Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) has two pleckstrin homology (PH) domains: an amino-terminal domain (PH1) and a split PH domain (PH2). Here, we show that overlay assay of bovine brain tubulin... -
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- Polymorphisms in RAS Guanyl-releasing Protein 3 are Associated with Chronic Liver Disease and Hepatocellular Carcinoma in a Korean Population
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Oh AR, Lee SK, Kim MH, Cheong JY, Cho SW, Yang KS, Kwack K
- KMID: 2166418
- Genomics Inform.
- 2008 Dec;6(4):181-191.
RAS guanyl-releasing protein 3 (RasGRP3), a member of the Ras subfamily of GTPases, functions as a guanosine triphosphate (GTP)/guanosine diphosphate (GDP)-regulated switch that cycles between inactive GDP- and active GTP-bound... -
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- Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly
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Kim SK, Kim H, Yang YR, Suh PG, Chang JS
- KMID: 1109404
- Exp Mol Med.
- 2011 Mar;43(3):153-160.
- doi: 10.3858/emm.2011.43.3.019
Phosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light chain (NF-L) self assembly, we... -
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- Preeclampsia serum-induced collagen I expression and intracellular calcium levels in arterial smooth muscle cells are mediated by the PLC-gamma1 pathway
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Jiang R, Teng Y, Huang Y, Gu J, Ma L, Li M, Zhou Y
- KMID: 2155380
- Exp Mol Med.
- 2014 Sep;46(9):e115.
- doi: 10.1038/emm.2014.59
In women with preeclampsia (PE), endothelial cell (EC) dysfunction can lead to altered secretion of paracrine factors that induce peripheral vasoconstriction and proteinuria. This study examined the hypothesis that PE... -
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- CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2+ Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells
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Nguyen YH, Lee KY, Kim TJ, Kim SJ, Kang TM
- KMID: 1448922
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):179-187.
- doi: 10.4196/kjpp.2011.15.3.179
Regulation of B cell receptor (BCR)-induced Ca2+ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature... -
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- The Effects of Baicalein on Osteoclast Differentiation from Bone Marrow Derived Macrophage
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Yun JK, Cheon YH, Kim JY, Kwak SC, Yoon KH, Baek JM, Lee MS, Oh J, Park J
- KMID: 1917128
- Korean J Phys Anthropol.
- 2014 Jun;27(2):91-99.
- doi: 10.11637/kjpa.2014.27.2.91
As prediction of rapidly aging society, bone health is considered increasingly important and received more attention than ever. Bone health is regulated by balancing between bone resorptive osteoclasts and bone... -
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- A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation
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Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS
- KMID: 946654
- Exp Mol Med.
- 2010 Mar;42(3):216-222.
- doi: 10.3858/emm.2010.42.3.023
Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,... -
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